The present study has analyzed a cardiovascular response in the sailors of a ship's crew (n = 23) on board the large self-reacting trawler "Konstantin Dushenov" during a fish-catching translatitudinal voyage for 5 months (181 days). The nonspecific mechanisms of adaptation in the seamen during long-term voyages are found to form by activating the central outlines of controlling. With the general trend for the activity of the sympathetic nervous system to decrease during the voyage, latter manifested itself under loads in a working cycle, by demonstrating the preserved responsiveness of the body in the sailors. By analyzing the results of the study, the authors show that there are the correlations between the parameters kept in mind, which allow the mechanisms of adjustment to be studied. The paper presents the results of informational simulation of correlation matrices with their high level of generalization where the time of course of adaptive changes to working conditions is demonstrated.