Digital radiography has been increasingly adopted since it can provide better image quality compared to conventional screen/film method. However, digital radiography can sometimes produce low-quality images because its processing algorithm is unaware of the content. Here, an adaptive multi-scale image enhancement algorithm for digital radiography is demonstrated. The algorithm adapts to the context of the image, thus providing better image quality. The qualitative and quantitative validations of the algorithm in phantoms and in clinical settings showed satisfactory performance.