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Belly-born B cells bathe the brain.
Stathopoulos PA, O'Connor KC. Stathopoulos PA, et al. Sci Immunol. 2019 Feb 1;4(32):eaaw7721. doi: 10.1126/sciimmunol.aaw7721. Sci Immunol. 2019. PMID: 30709846
IgA-expressing antibody secreting cells that are formed in the gut travel to the brain to diminish inflammation during multiple sclerosis exacerbations....
IgA-expressing antibody secreting cells that are formed in the gut travel to the brain to diminish inflammation during multiple scler
Host Selection of Microbiota via Differential Adhesion.
McLoughlin K, Schluter J, Rakoff-Nahoum S, Smith AL, Foster KR. McLoughlin K, et al. Cell Host Microbe. 2016 Apr 13;19(4):550-9. doi: 10.1016/j.chom.2016.02.021. Epub 2016 Mar 24. Cell Host Microbe. 2016. PMID: 27053168 Free article.
Our work predicts that adhesion is a powerful mechanism for both positive and negative selection within the microbiota. We discuss molecules-mucus glycans and IgA-that affect microbe adhesion and identify testable predictions of the adhesion-as-selection model....
Our work predicts that adhesion is a powerful mechanism for both positive and negative selection within the microbiota. We discuss molecules …
Timing of Elevations of Autoantibody Isotypes Prior to Diagnosis of Rheumatoid Arthritis.
Kelmenson LB, Wagner BD, McNair BK, Frazer-Abel A, Demoruelle MK, Bergstedt DT, Feser ML, Moss LK, Parish MC, Mewshaw EA, Mikuls TR, Edison JD, Holers VM, Deane KD. Kelmenson LB, et al. Arthritis Rheumatol. 2020 Feb;72(2):251-261. doi: 10.1002/art.41091. Epub 2019 Dec 26. Arthritis Rheumatol. 2020. PMID: 31464042 Free PMC article.

RESULTS: Autoantibody levels were elevated in cases versus controls a mean of 17.9 years before RA diagnosis for IgG ACPA, 14.2 years for IgA-RF, 7.2 years for IgM-RF, 6.2 years for IgA ACPA, and 5.0 years for both IgM ACPA and IgG-RF (P < 0.01 for all comparison

RESULTS: Autoantibody levels were elevated in cases versus controls a mean of 17.9 years before RA diagnosis for IgG ACPA, 14.2 years for …
GMP manufacture of Shigella flexneri 2a Artificial Invaplex (InvaplexAR) and evaluation in a Phase 1 Open-label, dose escalating study administered intranasally to healthy, adult volunteers.
Duplessis C, Clarkson KA, Ross Turbyfill K, Alcala AN, Gutierrez R, Riddle MS, Lee T, Paolino K, Weerts HP, Lynen A, Oaks EV, Porter CK, Kaminski R. Duplessis C, et al. Vaccine. 2023 Oct 6;41(42):6261-6271. doi: 10.1016/j.vaccine.2023.08.051. Epub 2023 Sep 2. Vaccine. 2023. PMID: 37666695 Free article.
Vaccination with Invaplex(AR) induced anti-LPS serum IgG responses and anti-Invaplex IgA and IgG antibody secreting cell (ASC) responses at vaccine doses 250 g. ...Notably, the responder rates and the kinetics of ASCs and antibody lymphocyte secretion (ALS) were similar, s …
Vaccination with Invaplex(AR) induced anti-LPS serum IgG responses and anti-Invaplex IgA and IgG antibody secreting cell (ASC) respon …
Phenotypic and Ig Repertoire Analyses Indicate a Common Origin of IgD-CD27- Double Negative B Cells in Healthy Individuals and Multiple Sclerosis Patients.
Fraussen J, Marquez S, Takata K, Beckers L, Montes Diaz G, Zografou C, Van Wijmeersch B, Villar LM, O'Connor KC, Kleinstein SH, Somers V. Fraussen J, et al. J Immunol. 2019 Sep 15;203(6):1650-1664. doi: 10.4049/jimmunol.1801236. Epub 2019 Aug 7. J Immunol. 2019. PMID: 31391234 Free PMC article.
Phenotypic analysis indicated a mature state of DN B cells by low CD5, CD10, and CD38 expression. However, the frequency of CD95(+) and IgA(+) cells was lower in DN versus CSM B cells. DN B cells are Ag experienced, as shown by somatic hypermutation of their Ig genes in ad …
Phenotypic analysis indicated a mature state of DN B cells by low CD5, CD10, and CD38 expression. However, the frequency of CD95(+) and I
A corn-fermented protein ingredient can be included in early nursey diets without compromising pig growth performance and health status.
Garavito-Duarte YR, Levesque CL, Herrick K, Perez-Palencia JY. Garavito-Duarte YR, et al. Transl Anim Sci. 2024 Jan 5;8:txad149. doi: 10.1093/tas/txad149. eCollection 2024. Transl Anim Sci. 2024. PMID: 38390272 Free PMC article.
Intestinal health was assessed based on plasma immunoglobulin A (IgA) concentration and the differential sugar absorption test. The total tract digestibility of dry matter (DM), crude protein (CP), gross energy (GE), and phosphorus was also evaluated. ...For the rest of th …
Intestinal health was assessed based on plasma immunoglobulin A (IgA) concentration and the differential sugar absorption test. The t …
IgG anti-tTG responses in different autoimmune conditions differ in their epitope targets and subclass usage.
Comerford R, Kelly J, Feighery C, Byrne G. Comerford R, et al. Mol Immunol. 2015 Oct;67(2 Pt B):369-76. doi: 10.1016/j.molimm.2015.06.026. Epub 2015 Jul 14. Mol Immunol. 2015. PMID: 26184652
Antibodies of the IgA class directed against the enzyme tissue transglutaminase (tTG) are highly specific for coeliac disease (CD). IgG antibodies to tTG also occur in CD, and have also been reported in autoimmune diseases such as type 1 diabetes mellitus and Crohn's disea …
Antibodies of the IgA class directed against the enzyme tissue transglutaminase (tTG) are highly specific for coeliac disease (CD). I …
Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator.
Baker KP, Edwards BM, Main SH, Choi GH, Wager RE, Halpern WG, Lappin PB, Riccobene T, Abramian D, Sekut L, Sturm B, Poortman C, Minter RR, Dobson CL, Williams E, Carmen S, Smith R, Roschke V, Hilbert DM, Vaughan TJ, Albert VR. Baker KP, et al. Arthritis Rheum. 2003 Nov;48(11):3253-65. doi: 10.1002/art.11299. Arthritis Rheum. 2003. PMID: 14613291 Free article.
LymphoStat-B potently inhibited BLyS-induced proliferation of B cells in vitro, and administration of LymphoStat-B to mice prevented human BLyS-induced increases in splenic B cell numbers and IgA titers. In cynomolgus monkeys, administration of LymphoStat-B resulted in dec …
LymphoStat-B potently inhibited BLyS-induced proliferation of B cells in vitro, and administration of LymphoStat-B to mice prevented human B …