Synthesis and Characterization of Phosphinecarboxamide and Phosphinecarbothioamide, and Their Complexation with Palladium(II) Complex

Reactions of isocyanates/isothiocyanates with primary and secondary phosphines without solvent at room temperature afforded phosphinecarboxamide/phosphinecarbothioamide, respectively, in excellent yields. Furthermore, palladium complex Pd(COD)Cl₂ was allowed to react with Ph₂PC(O)NHPh (1a) to afford [Pd{Ph₂PC(O)NHPh-κP}₂Cl₂] (3). On the other hand, the reaction of Pd(COD)Cl₂ with 1 eq. of Ph₂PC(S)NHPh (2a) afforded [PdCl₂{Ph₂PC(S)NHPh-κP,S}] (4). In the case of a 1:2 molar ratio, [PdCl{Ph₂PC(S)NHPh-κP,S}{Ph₂PC(S)NHPh-κP}]Cl (5) was formed. The newly obtained compounds were fully characterized using multielement NMR measurements and elemental analyses. In addition, the molecular structures of Ph₂PC(O)NH(CH₂)₂Cl (1j), Ph₂PC(S)NHPh(4-Cl) (2c), and 3-5 were determined using single-crystal X-ray diffraction.