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De novo phosphatidylcholine synthesis in the small intestinal epithelium is required for normal dietary lipid handling and maintenance of the mucosal barrier.
Carlin S, Kennelly JP, Fedoruk H, Quiroga A, Leonard KA, Nelson R, Thiesen A, Buteau J, Lehner R, Jacobs R. Carlin S, et al. Among authors: leonard ka. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Apr;1867(4):159109. doi: 10.1016/j.bbalip.2021.159109. Epub 2022 Jan 7. Biochim Biophys Acta Mol Cell Biol Lipids. 2022. PMID: 35007755
Choline deficiency impairs intestinal lipid metabolism in the lactating rat.
da Silva RP, Kelly KB, Lewis ED, Leonard KA, Goruk S, Curtis JM, Vine DF, Proctor SD, Field CJ, Jacobs RL. da Silva RP, et al. Among authors: leonard ka. J Nutr Biochem. 2015 Oct;26(10):1077-83. doi: 10.1016/j.jnutbio.2015.04.015. Epub 2015 May 29. J Nutr Biochem. 2015. PMID: 26092371
The marine compound and elongation factor 1A1 inhibitor, didemnin B, provides benefit in western diet-induced non-alcoholic fatty liver disease.
Wilson RB, Chen YJ, Sutherland BG, Sawyez CG, Zhang R, Woolnough T, Hetherington AM, Peters KM, Patel K, Kennelly JP, Leonard KA, Schuurman M, Jacobs RL, Wang R, Borradaile NM. Wilson RB, et al. Among authors: leonard ka. Pharmacol Res. 2020 Nov;161:105208. doi: 10.1016/j.phrs.2020.105208. Epub 2020 Sep 22. Pharmacol Res. 2020. PMID: 32977024 Free article.
11 results