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Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.
Lancet Oncol. 2017 Dec;18(12):1688-1700. doi: 10.1016/S1470-2045(17)30717-9. Epub 2017 Nov 13.
Lancet Oncol. 2017.
PMID: 29146401
Clinical Trial.
Older Adults' Views and Attitudes on Physical Activity; Reasons to Participate and Abstain.
Troutman-Jordan M, O'Brien T, Keaton M.
Troutman-Jordan M, et al. Among authors: keaton m.
J Community Health Nurs. 2021 Oct-Dec;38(4):232-243. doi: 10.1080/07370016.2021.1972247.
J Community Health Nurs. 2021.
PMID: 34787041
The purpose of this study was to identify facilitators and barriers to physical activity/exercise; gain greater understanding of older adults' physical activity self-efficacy; and increase understanding of how to reduce sedentary behavior.Design: Cross-sectional descriptiv …
The purpose of this study was to identify facilitators and barriers to physical activity/exercise; gain greater understanding of older adult …
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Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin.
Pai MT, Tzeng SR, Kovacs JJ, Keaton MA, Li SS, Yao TP, Zhou P.
Pai MT, et al. Among authors: keaton ma.
J Mol Biol. 2007 Jul 6;370(2):290-302. doi: 10.1016/j.jmb.2007.04.015. Epub 2007 Apr 12.
J Mol Biol. 2007.
PMID: 17512543
Free PMC article.
Unlike the BUZ domain from isopeptidase T (isoT) that contains a single zinc finger, the Ubp-M BUZ domain features three zinc-binding sites consisting of 12 residues. These zinc ligands form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the …
Unlike the BUZ domain from isopeptidase T (isoT) that contains a single zinc finger, the Ubp-M BUZ domain features three zinc-binding sites …
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CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.
Abbas T, Mueller AC, Shibata E, Keaton M, Rossi M, Dutta A.
Abbas T, et al. Among authors: keaton m.
Mol Cell. 2013 Mar 28;49(6):1147-58. doi: 10.1016/j.molcel.2013.02.003. Epub 2013 Mar 7.
Mol Cell. 2013.
PMID: 23478445
Free PMC article.
The migration of epithelial cells is also stimulated by CRL1(FBXO11)-mediated downregulation of Cdt2 and the consequent stabilization of Set8. This is an interesting example of cross-regulation between specific Cullin 4 and Cullin 1 E3 ubiquitin ligases and highlights the …
The migration of epithelial cells is also stimulated by CRL1(FBXO11)-mediated downregulation of Cdt2 and the consequent stabilization of Set …
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Regulation of TGF-beta signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.
Abbas T, Keaton M, Dutta A.
Abbas T, et al. Among authors: keaton m.
Cell Cycle. 2013 Jul 15;12(14):2175-82. doi: 10.4161/cc.25314.
Cell Cycle. 2013.
PMID: 23892434
Free PMC article.
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