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Page 1
Characterization of false positive, contaminant-driven mutagenicity in impurities associated with the sotorasib drug substance.
Regul Toxicol Pharmacol. 2022 Jun;131:105162. doi: 10.1016/j.yrtph.2022.105162. Epub 2022 Mar 21.
Regul Toxicol Pharmacol. 2022.
PMID: 35331777
Nonclinical Safety Profile of Sotorasib, a KRASG12C-Specific Covalent Inhibitor for the Treatment of KRAS p.G12C-Mutated Cancer.
Ishida K, Werner JA, Davies R, Fan F, Thomas B, Wahlstrom J, Lipford JR, Monticello T.
Ishida K, et al.
Int J Toxicol. 2021 Oct;40(5):427-441. doi: 10.1177/10915818211022965. Epub 2021 Jun 17.
Int J Toxicol. 2021.
PMID: 34137282
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Phosphatidylinositol 3-Kinase δ-Specific Inhibitor-Induced Changes in the Ovary and Testis in the Sprague Dawley Rat and Cynomolgus Monkey.
Ishida K, Werner JA, Lafleur M, Wisler J, Wannberg S, Kalanzi J, Bussiere JL, Monticello TM.
Ishida K, et al.
Int J Toxicol. 2021 Jul-Aug;40(4):344-354. doi: 10.1177/10915818211008175. Epub 2021 Apr 19.
Int J Toxicol. 2021.
PMID: 33866838
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Development of an ICOSL and BAFF bispecific inhibitor AMG 570 for systemic lupus erythematosus treatment.
Zhang M, Lee F, Knize A, Jacobsen F, Yu S, Ishida K, Miner K, Gaida K, Whoriskey J, Chen C, Gunasekaran K, Hsu H.
Zhang M, et al. Among authors: ishida k.
Clin Exp Rheumatol. 2019 Nov-Dec;37(6):906-914. Epub 2019 Feb 15.
Clin Exp Rheumatol. 2019.
PMID: 30789152
Free article.
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Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat.
Werner JA, Davies R, Wahlstrom J, Dahal UP, Jiang M, Stauber J, David B, Siska W, Thomas B, Ishida K, Humphreys WG, Lipford JR, Monticello TM.
Werner JA, et al. Among authors: ishida k.
Toxicol Appl Pharmacol. 2021 Jul 15;423:115578. doi: 10.1016/j.taap.2021.115578. Epub 2021 May 15.
Toxicol Appl Pharmacol. 2021.
PMID: 34004237
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Phosphatidylinositol 3-Kinase δ Inhibitor-Induced Immunomodulation and Secondary Opportunistic Infection in the Cynomolgus Monkey (Macaca fascicularis).
Werner JA, Ishida K, Wisler J, Karbowski C, Kalanzi J, Bussiere J, Monticello TM.
Werner JA, et al. Among authors: ishida k.
Toxicol Pathol. 2020 Dec;48(8):949-964. doi: 10.1177/0192623320966238. Epub 2020 Nov 28.
Toxicol Pathol. 2020.
PMID: 33252030
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