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Allele-specific DNA methylation reinforces PEAR1 enhancer activity.
Izzi B, Pistoni M, Cludts K, Akkor P, Lambrechts D, Verfaillie C, Verhamme P, Freson K, Hoylaerts MF. Izzi B, et al. Among authors: cludts k. Blood. 2016 Aug 18;128(7):1003-12. doi: 10.1182/blood-2015-11-682153. Epub 2016 Jun 16. Blood. 2016. PMID: 27313330 Free article.
Variation of PEAR1 DNA methylation influences platelet and leukocyte function.
Izzi B, Gianfagna F, Yang WY, Cludts K, De Curtis A, Verhamme P, Di Castelnuovo A, Cerletti C, Donati MB, de Gaetano G, Staessen JA, Hoylaerts MF, Iacoviello L; Moli-family Investigators. Izzi B, et al. Among authors: cludts k. Clin Epigenetics. 2019 Oct 29;11(1):151. doi: 10.1186/s13148-019-0744-8. Clin Epigenetics. 2019. PMID: 31665082 Free PMC article.
Dextran sulfate triggers platelet aggregation via direct activation of PEAR1.
Vandenbriele C, Sun Y, Criel M, Cludts K, Van Kerckhoven S, Izzi B, Vanassche T, Verhamme P, Hoylaerts MF. Vandenbriele C, et al. Among authors: cludts k. Platelets. 2016 Jun;27(4):365-72. doi: 10.3109/09537104.2015.1111321. Epub 2015 Nov 30. Platelets. 2016. PMID: 26619766
Modulation of thromboinflammation in hospitalized COVID-19 patients with aprotinin, low molecular weight heparin, and anakinra: The DAWn-Antico study.
Engelen MM, Van Thillo Q, Betrains A, Gyselinck I, Martens CP, Spalart V, Ockerman A, Devooght C, Wauters J, Gunst J, Wouters C, Vandenbriele C, Rex S, Liesenborghs L, Wilmer A, Meersseman P, Van den Berghe G, Dauwe D, Belmans A, Thomeer M, Fivez T, Mesotten D, Ruttens D, Heytens L, Dapper I, Tuyls S, De Tavernier B, Verhamme P, Vanassche T; DAWn Consortium Members. Engelen MM, et al. Res Pract Thromb Haemost. 2022 Oct 30;6(7):e12826. doi: 10.1002/rth2.12826. eCollection 2022 Oct. Res Pract Thromb Haemost. 2022. PMID: 36324831 Free PMC article.
Absence of Pear1 does not affect murine platelet function in vivo.
Criel M, Izzi B, Vandenbriele C, Liesenborghs L, Van Kerckhoven S, Lox M, Cludts K, Jones EA, Vanassche T, Verhamme P, Hoylaerts M. Criel M, et al. Among authors: cludts k. Thromb Res. 2016 Oct;146:76-83. doi: 10.1016/j.thromres.2016.08.026. Epub 2016 Aug 26. Thromb Res. 2016. PMID: 27614188