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Clinical validation of a next-generation sequencing-based multi-cancer early detection "liquid biopsy" blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs (CANDiD) study.
Flory A, Kruglyak KM, Tynan JA, McLennan LM, Rafalko JM, Fiaux PC, Hernandez GE, Marass F, Nakashe P, Ruiz-Perez CA, Fath DM, Jennings T, Motalli-Pepio R, Wotrang K, McCleary-Wheeler AL, Lana S, Phillips B, Flesner BK, Leibman NF, LaDue T, Tripp CD, Coomber BL, Woods JP, Miller M, Aiken SW, Wolf-Ringwall A, Borgatti A, Kraska K, Thomson CB, Kosanovich Cahalane A, Murray RL, Kisseberth WC, Camps-Palau MA, Floch F, Beaudu-Lange C, Klajer-Peres A, Keravel O, Fribourg-Blanc LA, Mazetier PC, Marco A, McLeod MB, Portillo E, Clark TS, Judd S, Feinberg CK, Benitez M, Runyan C, Hackett L, Lafey S, Richardson D, Vineyard S, Tefend Campbell M, Dharajiya N, Jensen TJ, van den Boom D, Diaz LA Jr, Grosu DS, Polk A, Marsal K, Hicks SC, Lytle KM, Holtvoigt L, Chibuk J, Chorny I, Tsui DWY. Flory A, et al. Among authors: lytle km. PLoS One. 2022 Apr 26;17(4):e0266623. doi: 10.1371/journal.pone.0266623. eCollection 2022. PLoS One. 2022. PMID: 35471999 Free PMC article.
Clinical experience with next-generation sequencing-based liquid biopsy testing for cancer detection in dogs: a review of 1,500 consecutive clinical cases.
O'Kell AL, Lytle KM, Cohen TA, Wong LK, Sandford E, Rafalko JM, Brandstetter G, DiMarzio LR, Phelps-Dunn A, Rosentel MC, Warren CD, McCleary-Wheeler AL, Fiaux PC, Marass F, Marshall MA, Ruiz-Perez CA, Kruglyak KM, Tynan JA, Hicks SC, Grosu DS, Chibuk J, Chorny I, Tsui DWY, Flory A. O'Kell AL, et al. Among authors: lytle km. J Am Vet Med Assoc. 2023 Mar 17;261(6):827-836. doi: 10.2460/javma.22.11.0526. Print 2023 Jun 1. J Am Vet Med Assoc. 2023. PMID: 36965477 Review.
Horizons in Veterinary Precision Oncology: Fundamentals of Cancer Genomics and Applications of Liquid Biopsy for the Detection, Characterization, and Management of Cancer in Dogs.
Chibuk J, Flory A, Kruglyak KM, Leibman N, Nahama A, Dharajiya N, van den Boom D, Jensen TJ, Friedman JS, Shen MR, Clemente-Vicario F, Chorny I, Tynan JA, Lytle KM, Holtvoigt LE, Murtaza M, Diaz LA Jr, Tsui DWY, Grosu DS. Chibuk J, et al. Among authors: lytle km. Front Vet Sci. 2021 Mar 23;8:664718. doi: 10.3389/fvets.2021.664718. eCollection 2021. Front Vet Sci. 2021. PMID: 33834049 Free PMC article. Review.
Genetic epidemiology of blood type, disease and trait variants, and genome-wide genetic diversity in over 11,000 domestic cats.
Anderson H, Davison S, Lytle KM, Honkanen L, Freyer J, Mathlin J, Kyöstilä K, Inman L, Louviere A, Chodroff Foran R, Forman OP, Lohi H, Donner J. Anderson H, et al. Among authors: lytle km. PLoS Genet. 2022 Jun 16;18(6):e1009804. doi: 10.1371/journal.pgen.1009804. eCollection 2022 Jun. PLoS Genet. 2022. PMID: 35709088 Free PMC article.
Detection of Age-Related Somatic Alterations in Canine Blood Using Next-Generation Sequencing-Based Liquid Biopsy: An Analysis of over 4800 Dogs.
Kruglyak KM, O'Kell AL, Cohen TA, Marshall MA, Ruiz-Perez CA, Marass F, Tynan JA, Hicks SC, Lytle KM, Phelps-Dunn A, Brandstetter G, Warren CD, DiMarzio LR, Rosentel MC, Wong LK, McLennan LM, Rafalko JM, Grosu DS, Chibuk J, Chorny I, McCleary-Wheeler AL, Flory A, Tsui DWY. Kruglyak KM, et al. Among authors: lytle km. Vet Sci. 2023 Jul 11;10(7):455. doi: 10.3390/vetsci10070455. Vet Sci. 2023. PMID: 37505860 Free PMC article.
Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs.
Donner J, Anderson H, Davison S, Hughes AM, Bouirmane J, Lindqvist J, Lytle KM, Ganesan B, Ottka C, Ruotanen P, Kaukonen M, Forman OP, Fretwell N, Cole CA, Lohi H. Donner J, et al. Among authors: lytle km. PLoS Genet. 2018 Apr 30;14(4):e1007361. doi: 10.1371/journal.pgen.1007361. eCollection 2018 Apr. PLoS Genet. 2018. PMID: 29708978 Free PMC article.
Correction: Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs.
Donner J, Anderson H, Davison S, Hughes AM, Bouirmane J, Lindqvist J, Lytle KM, Ganesan B, Ottka C, Ruotanen P, Kaukonen M, Forman OP, Fretwell N, Cole CA, Lohi H. Donner J, et al. Among authors: lytle km. PLoS Genet. 2019 Jan 18;15(1):e1007938. doi: 10.1371/journal.pgen.1007938. eCollection 2019 Jan. PLoS Genet. 2019. PMID: 30657768 Free PMC article.