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Extracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy.
van Beijnum JR, Huijbers EJM, van Loon K, Blanas A, Akbari P, Roos A, Wong TJ, Denisov SS, Hackeng TM, Jimenez CR, Nowak-Sliwinska P, Griffioen AW. van Beijnum JR, et al. Among authors: van loon k. Nat Commun. 2022 May 23;13(1):2842. doi: 10.1038/s41467-022-30063-7. Nat Commun. 2022. PMID: 35606362 Free PMC article.
Extracellular vimentin as a versatile immune suppressive protein in cancer.
van Loon K, van Breest Smallenburg ME, Huijbers EJM, Griffioen AW, van Beijnum JR. van Loon K, et al. Biochim Biophys Acta Rev Cancer. 2023 Nov;1878(6):188985. doi: 10.1016/j.bbcan.2023.188985. Epub 2023 Sep 17. Biochim Biophys Acta Rev Cancer. 2023. PMID: 37717859 Free article. Review.
Vaccination with a bacterial peptide conjugated to SARS-CoV-2 receptor-binding domain accelerates immunity and protects against COVID-19.
Blanas A, Karsjens H, de Ligt A, Huijbers EJM, van Loon K, Denisov SS, Durukan C, Engbersen DJM, Groen J, Hennig S, Hackeng TM, van Beijnum JR, Griffioen AW. Blanas A, et al. Among authors: van loon k. iScience. 2022 Aug 19;25(8):104719. doi: 10.1016/j.isci.2022.104719. Epub 2022 Jul 5. iScience. 2022. PMID: 35813877 Free PMC article.
FcγRIIB engagement drives agonistic activity of Fc-engineered αOX40 antibody to stimulate human tumor-infiltrating T cells.
Campos Carrascosa L, van Beek AA, de Ruiter V, Doukas M, Wei J, Fisher TS, Ching K, Yang W, van Loon K, Boor PPC, Rakké YS, Noordam L, Doornebosch P, Grünhagen D, Verhoef K, Polak WG, IJzermans JNM, Ni I, Yeung YA, Salek-Ardakani S, Sprengers D, Kwekkeboom J. Campos Carrascosa L, et al. Among authors: van loon k. J Immunother Cancer. 2020 Sep;8(2):e000816. doi: 10.1136/jitc-2020-000816. J Immunother Cancer. 2020. PMID: 32900860 Free PMC article.