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Substituted 3‑acyl‑2‑phenylamino‑1,4‑naphthoquinones intercalate into DNA and cause genotoxicity through the increased generation of reactive oxygen species culminating in cell death.
Farias MS, Pich CT, Kviecinski MR, Bucker NC, Felipe KB, Da Silva FO, Günther TM, Correia JF, Ríos D, Benites J, Valderrama JA, Calderon PB, Pedrosa RC. Farias MS, et al. Among authors: felipe kb. Mol Med Rep. 2014 Jul;10(1):405-10. doi: 10.3892/mmr.2014.2160. Epub 2014 Apr 16. Mol Med Rep. 2014. PMID: 24756411
Sodium orthovanadate associated with pharmacological doses of ascorbate causes an increased generation of ROS in tumor cells that inhibits proliferation and triggers apoptosis.
Günther TM, Kviecinski MR, Baron CC, Felipe KB, Farias MS, da Silva FO, Bücker NC, Pich CT, Ferreira EA, Wilhelm Filho D, Verrax J, Calderon PB, Pedrosa RC. Günther TM, et al. Among authors: felipe kb. Biochem Biophys Res Commun. 2013 Jan 18;430(3):883-8. doi: 10.1016/j.bbrc.2012.12.061. Epub 2012 Dec 19. Biochem Biophys Res Commun. 2013. PMID: 23261463 Free article.