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The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin-antitoxin and related phage defense systems.
Ernits K, Saha CK, Brodiazhenko T, Chouhan B, Shenoy A, Buttress JA, Duque-Pedraza JJ, Bojar V, Nakamoto JA, Kurata T, Egorov AA, Shyrokova L, Johansson MJO, Mets T, Rustamova A, Džigurski J, Tenson T, Garcia-Pino A, Strahl H, Elofsson A, Hauryliuk V, Atkinson GC. Ernits K, et al. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2305393120. doi: 10.1073/pnas.2305393120. Epub 2023 Aug 9. Proc Natl Acad Sci U S A. 2023. PMID: 37556498 Free PMC article.
Structure of SpoT reveals evolutionary tuning of catalysis via conformational constraint.
Tamman H, Ernits K, Roghanian M, Ainelo A, Julius C, Perrier A, Talavera A, Ainelo H, Dugauquier R, Zedek S, Thureau A, Pérez J, Lima-Mendez G, Hallez R, Atkinson GC, Hauryliuk V, Garcia-Pino A. Tamman H, et al. Among authors: ernits k. Nat Chem Biol. 2023 Mar;19(3):334-345. doi: 10.1038/s41589-022-01198-x. Epub 2022 Dec 5. Nat Chem Biol. 2023. PMID: 36470996 Free PMC article.
A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains.
Kurata T, Saha CK, Buttress JA, Mets T, Brodiazhenko T, Turnbull KJ, Awoyomi OF, Oliveira SRA, Jimmy S, Ernits K, Delannoy M, Persson K, Tenson T, Strahl H, Hauryliuk V, Atkinson GC. Kurata T, et al. Among authors: ernits k. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2102212119. doi: 10.1073/pnas.2102212119. Proc Natl Acad Sci U S A. 2022. PMID: 35121656 Free PMC article.
The structure of DarB in complex with RelNTD reveals nonribosomal activation of Rel stringent factors.
Ainelo A, Caballero-Montes J, Bulvas O, Ernits K, Coppieters 't Wallant K, Takada H, Craig SZ, Mazzucchelli G, Zedek S, Pichová I, Atkinson GC, Talavera A, Martens C, Hauryliuk V, Garcia-Pino A. Ainelo A, et al. Among authors: ernits k. Sci Adv. 2023 Jan 18;9(3):eade4077. doi: 10.1126/sciadv.ade4077. Epub 2023 Jan 18. Sci Adv. 2023. PMID: 36652515 Free PMC article.
Boosted production of antibodies that neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following messenger RNA vaccination - a case study.
Ravlo E, Ianevski A, Starheim E, Wang W, Ji P, Lysvand H, Smura T, Kivi G, Voolaid ML, Plaan K, Ustav M, Ustav M Jr, Zusinaite E, Tenson T, Kurg R, Oksenych V, Walstad K, Nordbø SA, Kaarbø M, Ernits K, Bjørås M, Kainov DE, Fenstad MH. Ravlo E, et al. Among authors: ernits k. Int J Infect Dis. 2023 Dec;137:75-78. doi: 10.1016/j.ijid.2023.10.011. Epub 2023 Oct 17. Int J Infect Dis. 2023. PMID: 37852599 Free article.
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