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Page 1
Inhibition of Insulin-Regulated Aminopeptidase by Imidazo [1,5-α]pyridines-Synthesis and Evaluation.
Int J Mol Sci. 2024 Feb 21;25(5):2516. doi: 10.3390/ijms25052516.
Int J Mol Sci. 2024.
PMID: 38473764
Free PMC article.
Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro-Oxindole Dihydroquinazolinones as IRAP Inhibitors.
Engen K, Vanga SR, Lundbäck T, Agalo F, Konda V, Jensen AJ, Åqvist J, Gutiérrez-de-Terán H, Hallberg M, Larhed M, Rosenström U.
Engen K, et al.
ChemistryOpen. 2020 Mar 2;9(3):325-337. doi: 10.1002/open.201900344. eCollection 2020 Mar.
ChemistryOpen. 2020.
PMID: 32154052
Free PMC article.
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Identification of Drug-Like Inhibitors of Insulin-Regulated Aminopeptidase Through Small-Molecule Screening.
Engen K, Rosenström U, Axelsson H, Konda V, Dahllund L, Otrocka M, Sigmundsson K, Nikolaou A, Vauquelin G, Hallberg M, Jenmalm Jensen A, Lundbäck T, Larhed M.
Engen K, et al.
Assay Drug Dev Technol. 2016 Apr;14(3):180-93. doi: 10.1089/adt.2016.708.
Assay Drug Dev Technol. 2016.
PMID: 27078680
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Chroman-4-one- and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells.
Seifert T, Malo M, Kokkola T, Engen K, Fridén-Saxin M, Wallén EA, Lahtela-Kakkonen M, Jarho EM, Luthman K.
Seifert T, et al. Among authors: engen k.
J Med Chem. 2014 Dec 11;57(23):9870-88. doi: 10.1021/jm500930h. Epub 2014 Dec 2.
J Med Chem. 2014.
PMID: 25383691
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Binding to and Inhibition of Insulin-Regulated Aminopeptidase by Macrocyclic Disulfides Enhances Spine Density.
Diwakarla S, Nylander E, Grönbladh A, Vanga SR, Khan YS, Gutiérrez-de-Terán H, Ng L, Pham V, Sävmarker J, Lundbäck T, Jenmalm-Jensen A, Andersson H, Engen K, Rosenström U, Larhed M, Åqvist J, Chai SY, Hallberg M.
Diwakarla S, et al. Among authors: engen k.
Mol Pharmacol. 2016 Apr;89(4):413-24. doi: 10.1124/mol.115.102533. Epub 2016 Jan 14.
Mol Pharmacol. 2016.
PMID: 26769413
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Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures.
Diwakarla S, Nylander E, Grönbladh A, Vanga SR, Shamsudin Y, Gutiérrez-de-Terán H, Sävmarker J, Ng L, Pham V, Lundbäck T, Jenmalm-Jensen A, Svensson R, Artursson P, Zelleroth S, Engen K, Rosenström U, Larhed M, Åqvist J, Chai SY, Hallberg M.
Diwakarla S, et al. Among authors: engen k.
ACS Chem Neurosci. 2016 Oct 19;7(10):1383-1392. doi: 10.1021/acschemneuro.6b00146. Epub 2016 Aug 8.
ACS Chem Neurosci. 2016.
PMID: 27501164
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Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates.
Svensson F, Engen K, Lundbäck T, Larhed M, Sköld C.
Svensson F, et al. Among authors: engen k.
J Chem Inf Model. 2015 Sep 28;55(9):1984-93. doi: 10.1021/acs.jcim.5b00359. Epub 2015 Aug 14.
J Chem Inf Model. 2015.
PMID: 26252078
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