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Distinct mode of action of a highly stable, engineered phage lysin killing Gram-negative bacteria.
Gerstmans H, Duyvejonck L, Vázquez R, Staes I, Borloo J, Abdelkader K, Leroy J, Cremelie E, Gutiérrez D, Tamés-Caunedo H, Ruas-Madiedo P, Rodríguez A, Aertsen A, Lammertyn J, Lavigne R, Briers Y. Gerstmans H, et al. Among authors: abdelkader k. Microbiol Spectr. 2023 Dec 12;11(6):e0181323. doi: 10.1128/spectrum.01813-23. Epub 2023 Nov 16. Microbiol Spectr. 2023. PMID: 37971248 Free PMC article.
Engineering a Lysin with Intrinsic Antibacterial Activity (LysMK34) by Cecropin A Fusion Enhances Its Antibacterial Properties against Acinetobacter baumannii.
Abdelkader K, Gutiérrez D, Tamés-Caunedo H, Ruas-Madiedo P, Safaan A, Khairalla AS, Gaber Y, Dishisha T, Briers Y. Abdelkader K, et al. Appl Environ Microbiol. 2022 Jan 11;88(1):e0151521. doi: 10.1128/AEM.01515-21. Epub 2021 Oct 20. Appl Environ Microbiol. 2022. PMID: 34669452 Free PMC article.
Lysin LysMK34 of Acinetobacter baumannii Bacteriophage PMK34 Has a Turgor Pressure-Dependent Intrinsic Antibacterial Activity and Reverts Colistin Resistance.
Abdelkader K, Gutiérrez D, Grimon D, Ruas-Madiedo P, Lood C, Lavigne R, Safaan A, Khairalla AS, Gaber Y, Dishisha T, Briers Y. Abdelkader K, et al. Appl Environ Microbiol. 2020 Sep 17;86(19):e01311-20. doi: 10.1128/AEM.01311-20. Print 2020 Sep 17. Appl Environ Microbiol. 2020. PMID: 32709718 Free PMC article.