Component Optimization of Neomycin Biosynthesis via the Reconstitution of a Combinatorial Mini-Gene-Cluster in Streptomyces fradiae.
Zheng J, Li Y, Guan H, Li J, Li D, Zhang J, Tan H.
Zheng J, et al.
ACS Synth Biol. 2020 Sep 18;9(9):2493-2501. doi: 10.1021/acssynbio.0c00281. Epub 2020 Aug 29.
ACS Synth Biol. 2020.
PMID: 32864952
In this work, the essential genes responsible for neomycin biosynthesis were evaluated and overexpressed to reduce the content of neomycin C. Among them, neoG and neoH are two novel regulatory genes for neomycin biosynthesis, aphA is a resistance gene, neoN encoding a radi …
In this work, the essential genes responsible for neomycin biosynthesis were evaluated and overexpressed to reduce the content of neomycin C …