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The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.
Int J Biochem Cell Biol. 2013 Jul;45(7):1195-203. doi: 10.1016/j.biocel.2013.03.012. Epub 2013 Mar 26.
Int J Biochem Cell Biol. 2013.
PMID: 23538298
Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth.
Hartmann D, Lucks J, Fuchs S, Schiffmann S, Schreiber Y, Ferreirós N, Merkens J, Marschalek R, Geisslinger G, Grösch S.
Hartmann D, et al.
Int J Biochem Cell Biol. 2012 Apr;44(4):620-8. doi: 10.1016/j.biocel.2011.12.019. Epub 2012 Jan 2.
Int J Biochem Cell Biol. 2012.
PMID: 22230369
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