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Page 1
Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase.
Markert C, Thoma G, Srinivas H, Bollbuck B, Lüönd RM, Miltz W, Wälchli R, Wolf R, Hinrichs J, Bergsdorf C, Azzaoui K, Penno CA, Klein K, Wack N, Jäger P, Hasler F, Beerli C, Loetscher P, Dawson J, Wieczorek G, Numao S, Littlewood-Evans A, Röhn TA. Markert C, et al. Among authors: klein k. J Med Chem. 2021 Feb 25;64(4):1889-1903. doi: 10.1021/acs.jmedchem.0c01955. Epub 2021 Feb 16. J Med Chem. 2021. PMID: 33592148
Potentiating Tweezer Affinity to a Protein Interface with Sequence-Defined Macromolecules on Nanoparticles.
Seiler T, Lennartz A, Klein K, Hommel K, Figueroa Bietti A, Hadrovic I, Kollenda S, Sager J, Beuck C, Chlosta E, Bayer P, Juul-Madsen K, Vorup-Jensen T, Schrader T, Epple M, Knauer SK, Hartmann L. Seiler T, et al. Among authors: klein k. Biomacromolecules. 2023 Aug 14;24(8):3666-3679. doi: 10.1021/acs.biomac.3c00393. Epub 2023 Jul 28. Biomacromolecules. 2023. PMID: 37507377
Silencing of proinflammatory NF-κB and inhibition of herpes simplex virus (HSV) replication by ultrasmall gold nanoparticles (2 nm) conjugated with small-interfering RNA.
Wolff N, Kollenda S, Klein K, Loza K, Heggen M, Brochhagen L, Witzke O, Krawczyk A, Hilger I, Epple M. Wolff N, et al. Among authors: klein k. Nanoscale Adv. 2022 Sep 5;4(21):4502-4516. doi: 10.1039/d2na00250g. eCollection 2022 Oct 25. Nanoscale Adv. 2022. PMID: 36341304 Free PMC article.
LTA4H inhibitor LYS006: Clinical PK/PD and safety in a randomized phase I clinical trial.
Loesche C, Picard D, Van Hoorick B, Schuhmann I, Jäger P, Klein K, Schuhler C, Thoma G, Markert C, Poller B, Zamurovic N, Weiss HM, Otto H, Fink M, Röhn TA. Loesche C, et al. Among authors: klein k. Clin Transl Sci. 2024 Feb;17(2):e13724. doi: 10.1111/cts.13724. Clin Transl Sci. 2024. PMID: 38407540 Free PMC article. Clinical Trial.