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2013 3
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Stable W/O/W multiple nanoemulsion encapsulating natural tocotrienols and caffeic acid with cisplatin synergistically treated cancer cell lines (A549 and HEP G2) and reduced toxicity on normal cell line (HEK 293).
Raviadaran R, Ng MH, Chandran D, Ooi KK, Manickam S. Raviadaran R, et al. Among authors: ooi kk. Mater Sci Eng C Mater Biol Appl. 2021 Feb;121:111808. doi: 10.1016/j.msec.2020.111808. Epub 2020 Dec 22. Mater Sci Eng C Mater Biol Appl. 2021. PMID: 33579452
10H-3,6-Diazaphenothiazine-Induced, Caspases-Mediated Mitochondrial-Dependent Apoptosis on HepG2 Hepatocellular Carcinoma Cells and Suppressed Cancer Cells Invasion via Inhibiting Mitochondrial Thioredoxin Reductase Enzymatic Activities.
Wang Y, Gao F, Ooi KK, Tai Q, Zhang J, Zhu Y, Kang J, Zhong F, Cai L, Fang F, Ang KP, Gao Y. Wang Y, et al. Among authors: ooi kk. J Environ Pathol Toxicol Oncol. 2019;38(4):297-311. doi: 10.1615/JEnvironPatholToxicolOncol.2019030482. J Environ Pathol Toxicol Oncol. 2019. PMID: 32464002
10H-3,6-Diazaphenothiazine induces G2/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NF-κB and (BIRC6-XIAP) complexes.
Zhang J, Ming C, Zhang W, Okechukwu PN, Morak-Młodawska B, Pluta K, Jeleń M, Akim AM, Ang KP, Ooi KK. Zhang J, et al. Among authors: ooi kk. Drug Des Devel Ther. 2017 Oct 24;11:3045-3063. doi: 10.2147/DDDT.S144415. eCollection 2017. Drug Des Devel Ther. 2017. PMID: 29123378 Free PMC article.
The influence of R substituents in triphenylphosphinegold(I) carbonimidothioates, Ph3PAu[SC(OR)=NPh] (R=Me, Et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways.
Yeo CI, Ooi KK, Akim AM, Ang KP, Fairuz ZA, Halim SN, Ng SW, Seng HL, Tiekink ER. Yeo CI, et al. Among authors: ooi kk. J Inorg Biochem. 2013 Oct;127:24-38. doi: 10.1016/j.jinorgbio.2013.05.011. Epub 2013 May 28. J Inorg Biochem. 2013. PMID: 23850666
Phosphanegold(I) thiolates, Ph3PAu[SC(OR)=NC 6H 4Me-4] for R = Me, Et and iPr, induce apoptosis, cell cycle arrest and inhibit cell invasion of HT-29 colon cancer cells through modulation of the nuclear factor-κB activation pathway and ubiquitination.
Ooi KK, Yeo CI, Ang KP, Akim AM, Cheah YK, Halim SN, Seng HL, Tiekink ER. Ooi KK, et al. J Biol Inorg Chem. 2015 Jul;20(5):855-73. doi: 10.1007/s00775-015-1271-5. Epub 2015 May 24. J Biol Inorg Chem. 2015. PMID: 26003312