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1994 1
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2008 2
2011 1
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2023 6
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Page 1
The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity.
Baumgartner CK, Ebrahimi-Nik H, Iracheta-Vellve A, Hamel KM, Olander KE, Davis TGR, McGuire KA, Halvorsen GT, Avila OI, Patel CH, Kim SY, Kammula AV, Muscato AJ, Halliwill K, Geda P, Klinge KL, Xiong Z, Duggan R, Mu L, Yeary MD, Patti JC, Balon TM, Mathew R, Backus C, Kennedy DE, Chen A, Longenecker K, Klahn JT, Hrusch CL, Krishnan N, Hutchins CW, Dunning JP, Bulic M, Tiwari P, Colvin KJ, Chuong CL, Kohnle IC, Rees MG, Boghossian A, Ronan M, Roth JA, Wu MJ, Suermondt JSMT, Knudsen NH, Cheruiyot CK, Sen DR, Griffin GK, Golub TR, El-Bardeesy N, Decker JH, Yang Y, Guffroy M, Fossey S, Trusk P, Sun IM, Liu Y, Qiu W, Sun Q, Paddock MN, Farney EP, Matulenko MA, Beauregard C, Frost JM, Yates KB, Kym PR, Manguso RT. Baumgartner CK, et al. Nature. 2023 Oct;622(7984):850-862. doi: 10.1038/s41586-023-06575-7. Epub 2023 Oct 4. Nature. 2023. PMID: 37794185 Free PMC article.
Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors.
Eckel-Passow JE, Lachance DH, Molinaro AM, Walsh KM, Decker PA, Sicotte H, Pekmezci M, Rice T, Kosel ML, Smirnov IV, Sarkar G, Caron AA, Kollmeyer TM, Praska CE, Chada AR, Halder C, Hansen HM, McCoy LS, Bracci PM, Marshall R, Zheng S, Reis GF, Pico AR, O'Neill BP, Buckner JC, Giannini C, Huse JT, Perry A, Tihan T, Berger MS, Chang SM, Prados MD, Wiemels J, Wiencke JK, Wrensch MR, Jenkins RB. Eckel-Passow JE, et al. N Engl J Med. 2015 Jun 25;372(26):2499-508. doi: 10.1056/NEJMoa1407279. Epub 2015 Jun 10. N Engl J Med. 2015. PMID: 26061753 Free PMC article.
Exploring Redox Modulation of Plant UDP-Glucose Pyrophosphorylase.
Decker D, Aubert J, Wilczynska M, Kleczkowski LA. Decker D, et al. Int J Mol Sci. 2023 May 17;24(10):8914. doi: 10.3390/ijms24108914. Int J Mol Sci. 2023. PMID: 37240260 Free PMC article.
Generally, while oxidative treatment decreased UGPase activity, a subsequent reduction restored the activity. The oxidized enzyme had increased K(m) values with substrates, especially pyrophosphate. The increased K(m) values were also observed, regardl …
Generally, while oxidative treatment decreased UGPase activity, a subsequent reduction restored the activity. The oxidized enzyme had increa …
Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer.
Sivakumar S, Jin DX, Tukachinsky H, Murugesan K, McGregor K, Danziger N, Pavlick D, Gjoerup O, Ross JS, Harmon R, Chung J, Decker B, Dennis L, Frampton GM, Molinero L, Oesterreich S, Venstrom JM, Oxnard GR, Hegde PS, Sokol ES. Sivakumar S, et al. Nat Commun. 2022 Dec 5;13(1):7495. doi: 10.1038/s41467-022-35245-x. Nat Commun. 2022. PMID: 36470901 Free PMC article.
Effects of Magnesium, Pyrophosphate and Phosphonates on Pyrophosphorolytic Reaction of UDP-Glucose Pyrophosphorylase.
Kleczkowski LA, Decker D. Kleczkowski LA, et al. Plants (Basel). 2022 Jun 20;11(12):1611. doi: 10.3390/plants11121611. Plants (Basel). 2022. PMID: 35736762 Free PMC article.
In the present study, we found that free magnesium (Mg(2+)) had profound effects on the reverse reaction of purified barley UGPase, and was absolutely required for its activity, with an apparent K(m) of 0.13 mM. More detailed analyses with varied concentrations of M …
In the present study, we found that free magnesium (Mg(2+)) had profound effects on the reverse reaction of purified barley UGPase, and was …
Anticoagulation in emergency general surgery: Who bleeds more? The EAST multicenter trials ACES study.
O'Meara L, Zhang A, Baum JN, Cooper A, Decker C, Schroeppel T, Cai J, Cullinane DC, Catalano RD, Bugaev N, LeClair MJ, Feather C, McBride K, Sams V, Leung PS, Olafson S, Callahan DS, Posluszny J, Moradian S, Estroff J, Hochman B, Coleman NL, Goldenberg-Sandau A, Nahmias J, Rosenbaum K, Pasley JD, Boll L, Hustad L, Reynolds J, Truitt M, Vesselinov R, Ghneim M. O'Meara L, et al. J Trauma Acute Care Surg. 2023 Oct 1;95(4):510-515. doi: 10.1097/TA.0000000000004042. Epub 2023 Jun 23. J Trauma Acute Care Surg. 2023. PMID: 37349868
Substrate Specificity and Inhibitor Sensitivity of Plant UDP-Sugar Producing Pyrophosphorylases.
Decker D, Kleczkowski LA. Decker D, et al. Front Plant Sci. 2017 Sep 20;8:1610. doi: 10.3389/fpls.2017.01610. eCollection 2017. Front Plant Sci. 2017. PMID: 28970843 Free PMC article.
USPase reacted with a range of sugar-1-phosphates, including D-Glc-1-P, D-Gal-1-P, D-GalA-1-P (K(m) of 1.3 mM), beta-L-Ara-1-P and alpha-D-Fuc-1-P (K(m) of 3.4 mM), but not beta-L-Fuc-1-P. In contrast, UAGPase2 reacted only with D-GlcNAc-1-P, D-GalNAc- …
USPase reacted with a range of sugar-1-phosphates, including D-Glc-1-P, D-Gal-1-P, D-GalA-1-P (K(m) of 1.3 mM), beta-L-Ara-1-P …
Engineering of a bacterial tyrosinase for improved catalytic efficiency towards D-tyrosine using random and site directed mutagenesis approaches.
Molloy S, Nikodinovic-Runic J, Martin LB, Hartmann H, Solano F, Decker H, O'Connor KE. Molloy S, et al. Biotechnol Bioeng. 2013 Jul;110(7):1849-57. doi: 10.1002/bit.24859. Epub 2013 Feb 22. Biotechnol Bioeng. 2013. PMID: 23381872
All single mutation variants based on RV145 had a higher k(cat) and K(m) value compared to the RV145 and thus the combination of four mutations in RV145 was antagonistic for turnover, but synergistic for affinity of the enzyme for D-tyrosine. Single mutation variant …
All single mutation variants based on RV145 had a higher k(cat) and K(m) value compared to the RV145 and thus the combination …
Development of serotonin transporter reuptake inhibition assays using JAR cells.
Decker AM, Blough BE. Decker AM, et al. J Pharmacol Toxicol Methods. 2018 Jul-Aug;92:52-56. doi: 10.1016/j.vascn.2018.03.003. Epub 2018 Mar 16. J Pharmacol Toxicol Methods. 2018. PMID: 29555537 Free PMC article.
METHODS: JAR cells were first shown to uptake [(3)H]serotonin in a saturable fashion with a K(M) value of 1 muM as determined by a Michaelis-Menten kinetic analysis. ...
METHODS: JAR cells were first shown to uptake [(3)H]serotonin in a saturable fashion with a K(M) value of 1 muM as determined …
25 results