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2003 1
2005 2
2006 1
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Page 1
Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.
McDowell CM, Kizhatil K, Elliott MH, Overby DR, van Batenburg-Sherwood J, Millar JC, Kuehn MH, Zode G, Acott TS, Anderson MG, Bhattacharya SK, Bertrand JA, Borras T, Bovenkamp DE, Cheng L, Danias J, De Ieso ML, Du Y, Faralli JA, Fuchshofer R, Ganapathy PS, Gong H, Herberg S, Hernandez H, Humphries P, John SWM, Kaufman PL, Keller KE, Kelley MJ, Kelly RA, Krizaj D, Kumar A, Leonard BC, Lieberman RL, Liton P, Liu Y, Liu KC, Lopez NN, Mao W, Mavlyutov T, McDonnell F, McLellan GJ, Mzyk P, Nartey A, Pasquale LR, Patel GC, Pattabiraman PP, Peters DM, Raghunathan V, Rao PV, Rayana N, Raychaudhuri U, Reina-Torres E, Ren R, Rhee D, Chowdhury UR, Samples JR, Samples EG, Sharif N, Schuman JS, Sheffield VC, Stevenson CH, Soundararajan A, Subramanian P, Sugali CK, Sun Y, Toris CB, Torrejon KY, Vahabikashi A, Vranka JA, Wang T, Willoughby CE, Xin C, Yun H, Zhang HF, Fautsch MP, Tamm ER, Clark AF, Ethier CR, Stamer WD. McDowell CM, et al. Invest Ophthalmol Vis Sci. 2022 Feb 1;63(2):12. doi: 10.1167/iovs.63.2.12. Invest Ophthalmol Vis Sci. 2022. PMID: 35129590 Free PMC article. Review.
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion.
Mlcochova P, Kemp SA, Dhar MS, Papa G, Meng B, Ferreira IATM, Datir R, Collier DA, Albecka A, Singh S, Pandey R, Brown J, Zhou J, Goonawardane N, Mishra S, Whittaker C, Mellan T, Marwal R, Datta M, Sengupta S, Ponnusamy K, Radhakrishnan VS, Abdullahi A, Charles O, Chattopadhyay P, Devi P, Caputo D, Peacock T, Wattal C, Goel N, Satwik A, Vaishya R, Agarwal M; Indian SARS-CoV-2 Genomics Consortium (INSACOG); Genotype to Phenotype Japan (G2P-Japan) Consortium; CITIID-NIHR BioResource COVID-19 Collaboration; Mavousian A, Lee JH, Bassi J, Silacci-Fegni C, Saliba C, Pinto D, Irie T, Yoshida I, Hamilton WL, Sato K, Bhatt S, Flaxman S, James LC, Corti D, Piccoli L, Barclay WS, Rakshit P, Agrawal A, Gupta RK. Mlcochova P, et al. Nature. 2021 Nov;599(7883):114-119. doi: 10.1038/s41586-021-03944-y. Epub 2021 Sep 6. Nature. 2021. PMID: 34488225 Free PMC article.
Cathepsin K Regulates Intraocular Pressure by Modulating Extracellular Matrix Remodeling and Actin-Bundling in the Trabecular Meshwork Outflow Pathway.
Soundararajan A, Ghag SA, Vuda SS, Wang T, Pattabiraman PP. Soundararajan A, et al. Cells. 2021 Oct 24;10(11):2864. doi: 10.3390/cells10112864. Cells. 2021. PMID: 34831087 Free PMC article.
The homeostasis of extracellular matrix (ECM) and actin dynamics in the trabecular meshwork (TM) outflow pathway plays a critical role in intraocular pressure (IOP) regulation. We studied the role of cathepsin K (CTSK), a lysosomal cysteine protease and a potent collagenas …
The homeostasis of extracellular matrix (ECM) and actin dynamics in the trabecular meshwork (TM) outflow pathway plays a critical role in in …
Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
Weidner P, Saar D, Söhn M, Schroeder T, Yu Y, Zöllner FG, Ponelies N, Zhou X, Zwicky A, Rohrbacher FN, Pattabiraman VR, Tanriver M, Bauer A, Ahmed H, Ametamey SM, Riffel P, Seger R, Bode JW, Wade RC, Ebert MPA, Kragelund BB, Burgermeister E. Weidner P, et al. Cancer Lett. 2024 Apr 28;588:216783. doi: 10.1016/j.canlet.2024.216783. Epub 2024 Mar 9. Cancer Lett. 2024. PMID: 38462034 Free article.
Inhibition of K-RAS effectors like B-RAF or MEK1/2 is accompanied by treatment resistance in cancer patients via re-activation of PI3K and Wnt signaling. ...Thus, MTMR7 mimicry peptide(s) could provide a novel strategy for targeting mutant K-RAS in cancers....
Inhibition of K-RAS effectors like B-RAF or MEK1/2 is accompanied by treatment resistance in cancer patients via re-activation of PI3 …
From genome to drug lead: identification of a small-molecule inhibitor of the SARS virus.
Dooley AJ, Shindo N, Taggart B, Park JG, Pang YP. Dooley AJ, et al. Bioorg Med Chem Lett. 2006 Feb 15;16(4):830-3. doi: 10.1016/j.bmcl.2005.11.018. Epub 2005 Dec 1. Bioorg Med Chem Lett. 2006. PMID: 16325400 Free PMC article.
Virtual screening, a fast, computational approach to identify drug leads [Perola, E.; Xu, K.; Kollmeyer, T. M.; Kaufmann, S. H.; Prendergast, F. G. J. Med. ...Lett.2003, 13, 3989; Rajnarayanan, R. V.; Dakshanamurthy, S.; Pattabiraman, N. Biochem. Biophys. Res. Commu …
Virtual screening, a fast, computational approach to identify drug leads [Perola, E.; Xu, K.; Kollmeyer, T. M.; Kaufmann, S. H.; Pren …
Uteroglobin suppresses SCCA gene expression associated with allergic asthma.
Ray R, Choi M, Zhang Z, Silverman GA, Askew D, Mukherjee AB. Ray R, et al. J Biol Chem. 2005 Mar 18;280(11):9761-4. doi: 10.1074/jbc.C400581200. Epub 2005 Jan 27. J Biol Chem. 2005. PMID: 15677460 Free article.
Notably, these responses are suppressed by recombinant UG treatment (Mandal, A. K., Zhang, Z., Ray, R., Choi, M. S., Chowdhury, B., Pattabiraman, N., and Mukherjee, A. ...
Notably, these responses are suppressed by recombinant UG treatment (Mandal, A. K., Zhang, Z., Ray, R., Choi, M. S., Chowdhury, B., …
Characterization of two forms of mouse salivary androgen-binding protein (ABP): implications for evolutionary relationships and ligand-binding function.
Karn RC, Laukaitis CM. Karn RC, et al. Biochemistry. 2003 Jun 17;42(23):7162-70. doi: 10.1021/bi027424l. Biochemistry. 2003. PMID: 12795612
., and Mornon, J.-P. (2000) Ann. N.Y. Acad. Sci. 923, 90-112; Pattabiraman, N., Matthews, J., Ward, K., Mantile-Selvaggi, G., Miele, L., and Mukherjee, A. (2000) Ann. ...In addition to the cDNAs, which represent those of the musculus subspecies of Mus musculus, we a …
., and Mornon, J.-P. (2000) Ann. N.Y. Acad. Sci. 923, 90-112; Pattabiraman, N., Matthews, J., Ward, K., Mantile-Selvaggi, G., …
Novel curcumin analog (cis-trans curcumin) as ligand to adenosine receptors A2A and A2B: potential for therapeutics.
Hamilton LJ, Walker M, Pattabiraman M, Zhong HA, Luedtke B, Chandra S. Hamilton LJ, et al. Pharmacol Res. 2021 Mar;165:105410. doi: 10.1016/j.phrs.2020.105410. Epub 2021 Jan 2. Pharmacol Res. 2021. PMID: 33401004 Free PMC article.
Competitive binding results indicated that CTCUR binds to both AR A(2A) and AR A(2B) with K(i) values of 5 muM and 7 muM, respectively, which is consistent with our docking results. ...
Competitive binding results indicated that CTCUR binds to both AR A(2A) and AR A(2B) with K(i) values of 5 muM and 7 muM, respectivel …
Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma.
Lin CW, Sherman B, Moore LA, Laethem CL, Lu DW, Pattabiraman PP, Rao PV, deLong MA, Kopczynski CC. Lin CW, et al. J Ocul Pharmacol Ther. 2018 Jan/Feb;34(1-2):40-51. doi: 10.1089/jop.2017.0023. Epub 2017 Jun 13. J Ocul Pharmacol Ther. 2018. PMID: 28609185 Free PMC article.
In vivo ocular pharmacokinetics was studied in Dutch Belted rabbits. RESULTS: Netarsudil inhibited kinases ROCK1 and ROCK2 with a K(i) of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC(50)s of 79 and 16 nM, respectively, and blocked the pr …
In vivo ocular pharmacokinetics was studied in Dutch Belted rabbits. RESULTS: Netarsudil inhibited kinases ROCK1 and ROCK2 with a K(i …
13 results