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Cholesterol Lowering in Intermediate-Risk Persons without Cardiovascular Disease.
Yusuf S, Bosch J, Dagenais G, Zhu J, Xavier D, Liu L, Pais P, López-Jaramillo P, Leiter LA, Dans A, Avezum A, Piegas LS, Parkhomenko A, Keltai K, Keltai M, Sliwa K, Peters RJ, Held C, Chazova I, Yusoff K, Lewis BS, Jansky P, Khunti K, Toff WD, Reid CM, Varigos J, Sanchez-Vallejo G, McKelvie R, Pogue J, Jung H, Gao P, Diaz R, Lonn E; HOPE-3 Investigators. Yusuf S, et al. N Engl J Med. 2016 May 26;374(21):2021-31. doi: 10.1056/NEJMoa1600176. Epub 2016 Apr 2. N Engl J Med. 2016. PMID: 27040132 Free article. Clinical Trial.
The first coprimary outcome occurred in 235 participants (3.7%) in the rosuvastatin group and in 304 participants (4.8%) in the placebo group (hazard ratio, 0.76; 95% confidence interval [CI], 0.64 to 0.91; P=0.002). The results for the second coprimary outcome were consis …
The first coprimary outcome occurred in 235 participants (3.7%) in the rosuvastatin group and in 304 participants (4.8%) in the placebo grou …
PET Imaging of VLA-4 in a New BRAFV600E Mouse Model of Melanoma.
Bellavia MC, Nyiranshuti L, Latoche JD, Ho KV, Fecek RJ, Taylor JL, Day KE, Nigam S, Pun M, Gallazzi F, Edinger RS, Storkus WJ, Patel RB, Anderson CJ. Bellavia MC, et al. Mol Imaging Biol. 2022 Jun;24(3):425-433. doi: 10.1007/s11307-021-01666-1. Epub 2021 Oct 25. Mol Imaging Biol. 2022. PMID: 34694528 Free PMC article.
RESULTS: [(64)Cu]-LLP2A demonstrated high binding affinity to BPRalpha (K(d) = 1.4 nM) but indeterminate binding to BPR cells. VLA-4(+) BPRalpha and B16F10 displayed comparable time-dependent [(64)Cu]-LLP2A internalization, whereas BPR internalization was undetectab …
RESULTS: [(64)Cu]-LLP2A demonstrated high binding affinity to BPRalpha (K(d) = 1.4 nM) but indeterminate binding to BPR cells. …
A new bioactive flavone glycoside from the seeds of Melilotus indica All.
Yadava RN, Jain S. Yadava RN, et al. J Asian Nat Prod Res. 2005 Aug;7(4):595-9. doi: 10.1080/10286020310001608949. J Asian Nat Prod Res. 2005. PMID: 16087633
Earlier workers have reported the presence of C-glycosides [Sayed, E.L., Ishak, M.S. and Mabry, T.J. (1997) Asian J. Chem., 9, 551], methylene-dioxypterocarpan (MIS6) [Saxena, V.K. and Nigam, S. (1997) Fitoterapia, 68, 343-345], pterocarpane (MIS2) [Saxena, V.K …
Earlier workers have reported the presence of C-glycosides [Sayed, E.L., Ishak, M.S. and Mabry, T.J. (1997) Asian J. Chem., 9, 551], methyle …
Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease.
Lonn EM, Bosch J, López-Jaramillo P, Zhu J, Liu L, Pais P, Diaz R, Xavier D, Sliwa K, Dans A, Avezum A, Piegas LS, Keltai K, Keltai M, Chazova I, Peters RJ, Held C, Yusoff K, Lewis BS, Jansky P, Parkhomenko A, Khunti K, Toff WD, Reid CM, Varigos J, Leiter LA, Molina DI, McKelvie R, Pogue J, Wilkinson J, Jung H, Dagenais G, Yusuf S; HOPE-3 Investigators. Lonn EM, et al. N Engl J Med. 2016 May 26;374(21):2009-20. doi: 10.1056/NEJMoa1600175. Epub 2016 Apr 2. N Engl J Med. 2016. PMID: 27041480 Free article. Clinical Trial.
The first coprimary outcome occurred in 260 participants (4.1%) in the active-treatment group and in 279 (4.4%) in the placebo group (hazard ratio, 0.93; 95% confidence interval [CI], 0.79 to 1.10; P=0.40); the second coprimary outcome occurred in 312 participants (4.9%) a …
The first coprimary outcome occurred in 260 participants (4.1%) in the active-treatment group and in 279 (4.4%) in the placebo group (hazard …
Regulation of mOAT-mediated organic anion transport by okadaic acid and protein kinase C in LLC-PK(1) cells.
You G, Kuze K, Kohanski RA, Amsler K, Henderson S. You G, et al. J Biol Chem. 2000 Apr 7;275(14):10278-84. doi: 10.1074/jbc.275.14.10278. J Biol Chem. 2000. PMID: 10744714 Free article.
We have previously cloned a cDNA encoding an organic anion transporter from mouse kidney (mOAT) (Lopez-Nieto, C. E., You, G., Bush, K. T., Barros, E. J. G., Beier, D. R., and Nigam, S. K. (1997) J. Biol. Chem. 272, 6471-6478; Kuze, K., Graves, …
We have previously cloned a cDNA encoding an organic anion transporter from mouse kidney (mOAT) (Lopez-Nieto, C. E., You, G., Bush, K …
Contrast Sensitivity Testing in Retinal Vein Occlusion Using a Novel Stimulus.
Mishra S, Maganti N, Squires N, Bomdica P, Nigam D, Shapiro A, Gill MK, Lyon AT, Mirza RG. Mishra S, et al. Transl Vis Sci Technol. 2020 Oct 27;9(11):29. doi: 10.1167/tvst.9.11.29. eCollection 2020 Oct. Transl Vis Sci Technol. 2020. PMID: 33173608 Free PMC article.
A significant difference was observed between the RVO eyes and the control eyes in PR log CS scores (P value = 0.0001) and in MDS alpha value (P value = 0.01). No difference in MDS beta value was found between the study groups (P value = 0.39). ...
A significant difference was observed between the RVO eyes and the control eyes in PR log CS scores (P value = 0.0001) and in MDS alp …
Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease.
Yusuf S, Lonn E, Pais P, Bosch J, López-Jaramillo P, Zhu J, Xavier D, Avezum A, Leiter LA, Piegas LS, Parkhomenko A, Keltai M, Keltai K, Sliwa K, Chazova I, Peters RJ, Held C, Yusoff K, Lewis BS, Jansky P, Khunti K, Toff WD, Reid CM, Varigos J, Accini JL, McKelvie R, Pogue J, Jung H, Liu L, Diaz R, Dans A, Dagenais G; HOPE-3 Investigators. Yusuf S, et al. N Engl J Med. 2016 May 26;374(21):2032-43. doi: 10.1056/NEJMoa1600177. Epub 2016 Apr 2. N Engl J Med. 2016. PMID: 27039945 Free article. Clinical Trial.
The first coprimary outcome occurred in 113 participants (3.6%) in the combined-therapy group and in 157 (5.0%) in the dual-placebo group (hazard ratio, 0.71; 95% confidence interval [CI], 0.56 to 0.90; P=0.005). The second coprimary outcome occurred in 136 participants (4 …
The first coprimary outcome occurred in 113 participants (3.6%) in the combined-therapy group and in 157 (5.0%) in the dual-placebo group (h …
Effects of blood pressure and lipid lowering on cognition: Results from the HOPE-3 study.
Bosch J, O'Donnell M, Swaminathan B, Lonn EM, Sharma M, Dagenais G, Diaz R, Khunti K, Lewis BS, Avezum A, Held C, Keltai M, Reid C, Toff WD, Dans A, Leiter LA, Sliwa K, Lee SF, Pogue JM, Hart R, Yusuf S; HOPE-3 Investigators. Bosch J, et al. Neurology. 2019 Mar 26;92(13):e1435-e1446. doi: 10.1212/WNL.0000000000007174. Epub 2019 Feb 27. Neurology. 2019. PMID: 30814321 Free PMC article.
Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling.
Nagle MA, Truong DM, Dnyanmote AV, Ahn SY, Eraly SA, Wu W, Nigam SK. Nagle MA, et al. J Biol Chem. 2011 Jan 7;286(1):243-51. doi: 10.1074/jbc.M110.139949. Epub 2010 Oct 4. J Biol Chem. 2011. PMID: 20921221 Free PMC article.
The organic anion transporters OAT1 (SLC22A6, originally identified by us as NKT) and OAT3 (SLC22A8) are critical for handling many toxins, metabolites, and drugs, including antivirals (Truong, D. M., Kaler, G., Khandelwal, A., Swaan, P. W., and Nigam, S. …
The organic anion transporters OAT1 (SLC22A6, originally identified by us as NKT) and OAT3 (SLC22A8) are critical for handling many toxins, …
Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice.
Eraly SA, Vallon V, Vaughn DA, Gangoiti JA, Richter K, Nagle M, Monte JC, Rieg T, Truong DM, Long JM, Barshop BA, Kaler G, Nigam SK. Eraly SA, et al. J Biol Chem. 2006 Feb 24;281(8):5072-83. doi: 10.1074/jbc.M508050200. Epub 2005 Dec 14. J Biol Chem. 2006. PMID: 16354673 Free article.
Organic anion transporter 1 (OAT1), originally identified as NKT (Lopez-Nieto, C. E., You, G., Bush, K. T., Barros, E. J. G., Beier, D. R., and Nigam, S. K. (1997) J. ...
Organic anion transporter 1 (OAT1), originally identified as NKT (Lopez-Nieto, C. E., You, G., Bush, K. T., Barros, E. J. G., Beier, …
14 results