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Dipeptidyl peptidase-4 independent cardiac dysfunction links saxagliptin to heart failure.
Koyani CN, Kolesnik E, Wölkart G, Shrestha N, Scheruebel S, Trummer C, Zorn-Pauly K, Hammer A, Lang P, Reicher H, Maechler H, Groschner K, Mayer B, Rainer PP, Sourij H, Sattler W, Malle E, Pelzmann B, von Lewinski D. Koyani CN, et al. Biochem Pharmacol. 2017 Dec 1;145:64-80. doi: 10.1016/j.bcp.2017.08.021. Epub 2017 Aug 30. Biochem Pharmacol. 2017. PMID: 28859968 Free article.
Furthermore, saxagliptin reduced protein kinase C-mediated delayed rectifier K(+) current that prolonged action potential duration and consequently QTc interval. ...
Furthermore, saxagliptin reduced protein kinase C-mediated delayed rectifier K(+) current that prolonged action potential duration an …
Sustained Formation of Nitroglycerin-Derived Nitric Oxide by Aldehyde Dehydrogenase-2 in Vascular Smooth Muscle without Added Reductants: Implications for the Development of Nitrate Tolerance.
Opelt M, Wölkart G, Eroglu E, Waldeck-Weiermair M, Malli R, Graier WF, Kollau A, Fassett JT, Schrammel A, Mayer B, Gorren ACF. Opelt M, et al. Mol Pharmacol. 2018 Apr;93(4):335-343. doi: 10.1124/mol.117.110783. Epub 2018 Jan 22. Mol Pharmacol. 2018. PMID: 29358221 Free PMC article.
Relaxant effect of C-type natriuretic peptide involves endothelium and nitric oxide-cGMP system in rat coronary microvasculature.
Brunner F, Wölkart G. Brunner F, et al. Cardiovasc Res. 2001 Aug 15;51(3):577-84. doi: 10.1016/s0008-6363(01)00283-8. Cardiovasc Res. 2001. PMID: 11476748
METHODS: Rat hearts (n=6 per group) were perfused in vitro at constant flow and the effect of CNP (0.1-3 micromol/l) on coronary perfusion pressure (a measure of vascular tone) and release of guanosine 3',5'-cyclic monophosphate (cGMP) was determined in absence and presence of th …
METHODS: Rat hearts (n=6 per group) were perfused in vitro at constant flow and the effect of CNP (0.1-3 micromol/l) on coronary perfusion p …