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Characterization of neurotropic HPAI H5N1 viruses with novel genome constellations and mammalian adaptive mutations in free-living mesocarnivores in Canada.
Alkie TN, Cox S, Embury-Hyatt C, Stevens B, Pople N, Pybus MJ, Xu W, Hisanaga T, Suderman M, Koziuk J, Kruczkiewicz P, Nguyen HH, Fisher M, Lung O, Erdelyan CNG, Hochman O, Ojkic D, Yason C, Bravo-Araya M, Bourque L, Bollinger TK, Soos C, Giacinti J, Provencher J, Ogilvie S, Clark A, MacPhee R, Parsons GJ, Eaglesome H, Gilbert S, Saboraki K, Davis R, Jerao A, Ginn M, Jones MEB, Berhane Y. Alkie TN, et al. Emerg Microbes Infect. 2023 Dec;12(1):2186608. doi: 10.1080/22221751.2023.2186608. Emerg Microbes Infect. 2023. PMID: 36880345 Free PMC article.
Almost 17 percent of the H5N1 viruses had mammalian adaptive mutations (E627 K, E627V and D701N) in the polymerase basic protein 2 (PB2) subunit of the RNA polymerase complex. ...
Almost 17 percent of the H5N1 viruses had mammalian adaptive mutations (E627 K, E627V and D701N) in the polymerase basic protein 2 (P …
Protein engineering of a nanoCLAMP antibody mimetic scaffold as a platform for producing bioprocess-compatible affinity capture ligands.
Suderman RJ, Gibson SD, Strecker M, Bonner AM, Chao DM. Suderman RJ, et al. J Biol Chem. 2023 Jul;299(7):104910. doi: 10.1016/j.jbc.2023.104910. Epub 2023 Jun 12. J Biol Chem. 2023. PMID: 37315789 Free PMC article.
We then performed an in-depth characterization of nanoCLAMPs recognizing yeast SUMO, a fusion partner used for the purification of recombinant proteins. These second-generation nanoCLAMPs typically had a K(d) of <80 nM, a T(m) of >70 C, and a t(1/2) in 0.1 mg/ml tryp …
We then performed an in-depth characterization of nanoCLAMPs recognizing yeast SUMO, a fusion partner used for the purification of recombina …
Neutralization of SARS-CoV-2 and Intranasal Protection of Mice with a nanoCLAMP Antibody Mimetic.
Pagneux Q, Garnier N, Fabregue M, Sharkaoui S, Mazzoli S, Engelmann I, Boukherroub R, Strecker M, Cruz E, Ducos P, Szunerits S, Zarubica A, Suderman R. Pagneux Q, et al. ACS Pharmacol Transl Sci. 2024 Feb 1;7(3):757-770. doi: 10.1021/acsptsci.3c00306. eCollection 2024 Mar 8. ACS Pharmacol Transl Sci. 2024. PMID: 38481677
The resulting multimerized nanoCLAMP P2712 had sub-pM affinity for the Wuhan and South African (B.1.351) RBD (K(D) < 1 pM) and decreasing affinity for the Delta (B.1.617.2) and Omicron (B.1.1.529) variants (86 pM and 19.7 nM, respectively). ...

The resulting multimerized nanoCLAMP P2712 had sub-pM affinity for the Wuhan and South African (B.1.351) RBD (K(D) < 1 pM) and dec

…
Genome-wide DNA methylation variability in adolescent monozygotic twins followed since birth.
Lévesque ML, Casey KF, Szyf M, Ismaylova E, Ly V, Verner MP, Suderman M, Brendgen M, Vitaro F, Dionne G, Boivin M, Tremblay RE, Booij L. Lévesque ML, et al. Epigenetics. 2014 Oct;9(10):1410-21. doi: 10.4161/15592294.2014.970060. Epigenetics. 2014. PMID: 25437055 Free PMC article.
However, little is known about the variability of DNA methylation patterns in adolescence, a period involving significant and rapid physical, emotional, social, and neurodevelopmental change. Here, we assessed genome-wide DNA methylation using the 450 K Illumina BeadChip i …
However, little is known about the variability of DNA methylation patterns in adolescence, a period involving significant and rapid physical …
Assessing the role of genome-wide DNA methylation between smoking and risk of lung cancer using repeated measurements: the HUNT study.
Sun YQ, Richmond RC, Suderman M, Min JL, Battram T, Flatberg A, Beisvag V, Nøst TH, Guida F, Jiang L, Wahl SGF, Langhammer A, Skorpen F, Walker RM, Bretherick AD, Zeng Y, Chen Y, Johansson M, Sandanger TM, Relton CL, Mai XM. Sun YQ, et al. Int J Epidemiol. 2021 Nov 10;50(5):1482-1497. doi: 10.1093/ije/dyab044. Int J Epidemiol. 2021. PMID: 33729499 Free PMC article.
METHODS: We derived a nested case-control study from the Trondelag Health Study (HUNT), including 140 incident patients who developed lung cancer during 2009-13 and 140 controls. We profiled 850 K DNA methylation sites (Illumina Infinium EPIC array) in DNA extracted from b …
METHODS: We derived a nested case-control study from the Trondelag Health Study (HUNT), including 140 incident patients who developed lung c …
Maternal diet in pregnancy and child's respiratory outcomes: an individual participant data meta-analysis of 18 000 children.
Mensink-Bout SM, van Meel ER, de Jongste JC, Annesi-Maesano I, Aubert AM, Bernard JY, Chen LW, Cooper C, Crozier SR, Hanke W, Harvey NC, Hébert JR, Heude B, Jerzynska J, Kelleher CC, Mehegan J, McAuliffe FM, Phillips CM, Polanska K, Relton CL, Shivappa N, Suderman M, Jaddoe VWV, Duijts L. Mensink-Bout SM, et al. Eur Respir J. 2022 Apr 21;59(4):2101315. doi: 10.1183/13993003.01315-2021. Print 2022 Apr. Eur Respir J. 2022. PMID: 34503987 Free PMC article.
DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan.
van Dongen J, Hagenbeek FA, Suderman M, Roetman PJ, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty JD, Adams MJ, Walker RM, Morris SW, Lahti J, Küpers LK, Escaramis G, Alemany S, Jan Bonder M, Meijer M, Ip HF, Jansen R, Baselmans BML, Parmar P, Lowry E, Streit F, Sirignano L, Send TS, Frank J, Jylhävä J, Wang Y, Mishra PP, Colins OF, Corcoran DL, Poulton R, Mill J, Hannon E, Arseneault L, Korhonen T, Vuoksimaa E, Felix JF, Bakermans-Kranenburg MJ, Campbell A, Czamara D, Binder E, Corpeleijn E, Gonzalez JR, Grazuleviciene R, Gutzkow KB, Evandt J, Vafeiadi M, Klein M, van der Meer D, Ligthart L; BIOS Consortium; Kluft C, Davies GE, Hakulinen C, Keltikangas-Järvinen L, Franke B, Freitag CM, Konrad K, Hervas A, Fernández-Rivas A, Vetro A, Raitakari O, Lehtimäki T, Vermeiren R, Strandberg T, Räikkönen K, Snieder H, Witt SH, Deuschle M, Pedersen NL, Hägg S, Sunyer J, Franke L, Kaprio J, Ollikainen M, Moffitt TE, Tiemeier H, van IJzendoorn MH, Relton C, Vrijheid M, Sebert S, Jarvelin MR, Caspi A, Evans KL, McIntosh AM, Bartels M, Boomsma DI. van Dongen J, et al. Mol Psychiatry. 2021 Jun;26(6):2148-2162. doi: 10.1038/s41380-020-00987-x. Epub 2021 Jan 8. Mol Psychiatry. 2021. PMID: 33420481 Free PMC article.
Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi.
Nemoda Z, Massart R, Suderman M, Hallett M, Li T, Coote M, Cody N, Sun ZS, Soares CN, Turecki G, Steiner M, Szyf M. Nemoda Z, et al. Transl Psychiatry. 2015 Apr 7;5(4):e545. doi: 10.1038/tp.2015.32. Transl Psychiatry. 2015. PMID: 25849984 Free PMC article.
Genome-wide DNA methylation of CD3+ T lymphocytes isolated from 38 antepartum maternal and 44 neonatal cord blood samples were analyzed using Illumina Methylation 450 K microarrays. Previously obtained methylation data sets using methylated DNA immunoprecipitation and arra …
Genome-wide DNA methylation of CD3+ T lymphocytes isolated from 38 antepartum maternal and 44 neonatal cord blood samples were analyzed usin …