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In vitro and in vivo metabolisms of K-48.
Benko B, Kalász H, Ludányi K, Petroianu G, Kuca K, Darvas F, Tekes K. Benko B, et al. Anal Bioanal Chem. 2007 Oct;389(4):1243-7. doi: 10.1007/s00216-007-1507-5. Epub 2007 Sep 3. Anal Bioanal Chem. 2007. PMID: 17768608
Metabolic pathways of the oxime K-48 have been elucidated by means of in vitro and in vivo experiments. ...The in vivo metabolism in rats was investigated after intramuscular administration of 50 mumol oxime. K-48 was present in the rat serum in unchanged form. Simi …
Metabolic pathways of the oxime K-48 have been elucidated by means of in vitro and in vivo experiments. ...The in vivo metabolism in …
HPLC analysis of K-48 concentration in plasma.
Kalász H, Hasan MY, Sheen R, Kuca K, Petroianu G, Ludányi K, Gergely A, Tekes K. Kalász H, et al. Anal Bioanal Chem. 2006 Jul;385(6):1062-7. doi: 10.1007/s00216-006-0490-6. Epub 2006 Jun 9. Anal Bioanal Chem. 2006. PMID: 16763789
K-48 is a new oxime-type compound to be used as an enzyme reactivator in the treatment of exposure to organophosphorous compounds. ...K-48 displays a relatively high dose-normalized area under the curve as compared to pralidoxime, which might be beneficial for an an …
K-48 is a new oxime-type compound to be used as an enzyme reactivator in the treatment of exposure to organophosphorous compounds. .. …
High-performance liquid chromatographic determination of the plasma concentration of K-27, a novel oxime-type cholinesterase reactivator.
Tekes K, Hasan MY, Sheen R, Kuca K, Petroianu G, Ludányi K, Kalász H. Tekes K, et al. J Chromatogr A. 2006 Jul 28;1122(1-2):84-7. doi: 10.1016/j.chroma.2006.04.016. Epub 2006 May 11. J Chromatogr A. 2006. PMID: 16690067
Following intramuscular administration of 50 micromol (22.31 mg) K-27 in rats, the maximum of K-27 concentration in plasma was reached at about 15 min giving 186 microg/mL and the t(1/2) was 85 min. K-27 displays initial (from 15 trough 120 min) zero order el …
Following intramuscular administration of 50 micromol (22.31 mg) K-27 in rats, the maximum of K-27 concentration in plasma was …
New phenotypic, functional and electrophysiological characteristics of KG-1 cells.
Hajas G, Zsiros E, László T, Hajdú P, Somodi S, Réthi B, Gogolák P, Ludányi K, Panyi G, Rajnavölgyi E. Hajas G, et al. Immunol Lett. 2004 Mar 29;92(1-2):97-106. doi: 10.1016/j.imlet.2003.11.021. Immunol Lett. 2004. PMID: 15081533
We found that both unstimulated and activated KG-1 cells expressed time- and voltage-independent, ChTx sensitive intracellular Ca(2+)-gated potassium conductance suggesting the presence of K(Ca) channels in their membranes. Based on our results we propose that KG-1 cells r …
We found that both unstimulated and activated KG-1 cells expressed time- and voltage-independent, ChTx sensitive intracellular Ca(2+)-gated …