N-monosubstituted thiosemicarbazide as novel Ure inhibitors: synthesis, biological evaluation and molecular docking.
Ni WW, Fang HL, Ye YX, Li WY, Yuan CP, Li DD, Mao SJ, Li SE, Zhu QH, Ouyang H, Xiao ZP, Zhu HL.
Ni WW, et al.
Future Med Chem. 2020 Sep;12(18):1633-1645. doi: 10.4155/fmc-2020-0048. Epub 2020 Sep 7.
Future Med Chem. 2020.
PMID: 32892642
Out of these compounds, compound b5 shows excellent activity against both crude Ure from Helicobacter pylori (IC(50) = 0.04 muM) and Ure in living cell (IC(50) = 0.27 muM), with the potency being over 600-fold higher than clinical used drug acetohyroxamic acid, respectively. Surf …
Out of these compounds, compound b5 shows excellent activity against both crude Ure from Helicobacter pylori (IC(50) = 0.04 muM) and Ure in …