Intratumoral dendritic cell-CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma.
Magen A, Hamon P, Fiaschi N, Soong BY, Park MD, Mattiuz R, Humblin E, Troncoso L, D'souza D, Dawson T, Kim J, Hamel S, Buckup M, Chang C, Tabachnikova A, Schwartz H, Malissen N, Lavin Y, Soares-Schanoski A, Giotti B, Hegde S, Ioannou G, Gonzalez-Kozlova E, Hennequin C, Le Berichel J, Zhao Z, Ward SC, Fiel I, Kou B, Dobosz M, Li L, Adler C, Ni M, Wei Y, Wang W, Atwal GS, Kundu K, Cygan KJ, Tsankov AM, Rahman A, Price C, Fernandez N, He J, Gupta NT, Kim-Schulze S, Gnjatic S, Kenigsberg E, Deering RP, Schwartz M, Marron TU, Thurston G, Kamphorst AO, Merad M.
Magen A, et al.
Nat Med. 2023 Jun;29(6):1389-1399. doi: 10.1038/s41591-023-02345-0. Epub 2023 Jun 15.
Nat Med. 2023.
PMID: 37322116
We show that ICB response correlated with the clonal expansion of intratumoral CXCL13(+)CH25H(+)IL-21(+)PD-1(+)CD4(+) T helper cells ("CXCL13(+) T(H)") and Granzyme K(+) PD-1(+) effector-like CD8(+) T cells, whereas terminally exhausted CD39(hi)TOX(hi)PD-1(hi)CD8(+) T cell …
We show that ICB response correlated with the clonal expansion of intratumoral CXCL13(+)CH25H(+)IL-21(+)PD-1(+)CD4(+) T helper cells ("CXCL1 …