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Bacterial susceptibility and resistance to modelin-5.
Dennison SR, Morton LH, Badiani K, Harris F, Phoenix DA. Dennison SR, et al. Soft Matter. 2023 Nov 1;19(42):8247-8263. doi: 10.1039/d3sm01007d. Soft Matter. 2023. PMID: 37869970
Modelin-5 (M5-NH(2)) killed Pseudomonas aeruginosa with a minimum lethal concentration (MLC) of 5.86 muM and strongly bound its cytoplasmic membrane (CM) with a K(d) of 23.5 muM. The peptide adopted high levels of amphiphilic alpha-helical structure (75.0%) and penetrated …
Modelin-5 (M5-NH(2)) killed Pseudomonas aeruginosa with a minimum lethal concentration (MLC) of 5.86 muM and strongly bound its cytoplasmic …