SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.
Xue Y, Morris JL, Yang K, Fu Z, Zhu X, Johnson F, Meehan B, Witkowski L, Yasmeen A, Golenar T, Coatham M, Morin G, Monast A, Pilon V, Fiset PO, Jung S, Gonzalez AV, Camilleri-Broet S, Fu L, Postovit LM, Spicer J, Gotlieb WH, Guiot MC, Rak J, Park M, Lockwood W, Foulkes WD, Prudent J, Huang S.
Xue Y, et al.
Nat Commun. 2021 Sep 13;12(1):5404. doi: 10.1038/s41467-021-25260-9.
Nat Commun. 2021.
PMID: 34518526
Free PMC article.
By restricting chromatin accessibility to ITPR3, encoding Ca(2+) channel IP3R3, SMARCA4/2 deficiency causes reduced IP3R3 expression leading to impaired Ca(2+) transfer from the endoplasmic reticulum to mitochondria required for apoptosis induction. ...
By restricting chromatin accessibility to ITPR3, encoding Ca(2+) channel IP3R3, SMARCA4/2 deficiency causes reduced IP3R3 expression …