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A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro.
De Castro S, Stevaert A, Maldonado M, Delpal A, Vandeput J, Van Loy B, Eydoux C, Guillemot JC, Decroly E, Gago F, Canard B, Camarasa MJ, Velázquez S, Naesens L. De Castro S, et al. Among authors: vandeput j. Pharmaceuticals (Basel). 2022 Aug 18;15(8):1021. doi: 10.3390/ph15081021. Pharmaceuticals (Basel). 2022. PMID: 36015168 Free PMC article.
The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airways.
Laporte M, Raeymaekers V, Van Berwaer R, Vandeput J, Marchand-Casas I, Thibaut HJ, Van Looveren D, Martens K, Hoffmann M, Maes P, Pöhlmann S, Naesens L, Stevaert A. Laporte M, et al. Among authors: vandeput j. PLoS Pathog. 2021 Apr 22;17(4):e1009500. doi: 10.1371/journal.ppat.1009500. eCollection 2021 Apr. PLoS Pathog. 2021. PMID: 33886690 Free PMC article.