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Venetoclax is a potent hepsin inhibitor that reduces the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells.
Rodenas MC, Peñas-Martínez J, Pardo-Sánchez I, Zaragoza-Huesca D, Ortega-Sabater C, Peña-García J, Espín S, Ricote G, Montenegro S, Ayala-De La Peña F, Luengo-Gil G, Nieto A, García-Molina F, Vicente V, Bernardi F, Lozano ML, Mulero V, Pérez-Sánchez H, Carmona-Bayonas A, Martínez-Martínez I. Rodenas MC, et al. Among authors: penas martinez j. Front Mol Biosci. 2023 May 19;10:1182925. doi: 10.3389/fmolb.2023.1182925. eCollection 2023. Front Mol Biosci. 2023. PMID: 37275957 Free PMC article.
Anti-Tumor Functions of Prelatent Antithrombin on Glioblastoma Multiforme Cells.
Peñas-Martínez J, Luengo-Gil G, Espín S, Bohdan N, Ortega-Sabater C, Ródenas MC, Zaragoza-Huesca D, López-Andreo MJ, Plasencia C, Vicente V, Carmona-Bayonas A, Martínez-Martínez I. Peñas-Martínez J, et al. Biomedicines. 2021 May 7;9(5):523. doi: 10.3390/biomedicines9050523. Biomedicines. 2021. PMID: 34067120 Free PMC article.
Identification of Kukoamine A, Zeaxanthin, and Clexane as New Furin Inhibitors.
Zaragoza-Huesca D, Martínez-Cortés C, Banegas-Luna AJ, Pérez-Garrido A, Vegara-Meseguer JM, Peñas-Martínez J, Rodenas MC, Espín S, Pérez-Sánchez H, Martínez-Martínez I. Zaragoza-Huesca D, et al. Among authors: penas martinez j. Int J Mol Sci. 2022 Mar 3;23(5):2796. doi: 10.3390/ijms23052796. Int J Mol Sci. 2022. PMID: 35269938 Free PMC article.
Implication of Hepsin from Primary Tumor in the Prognosis of Colorectal Cancer Patients.
Zaragoza-Huesca D, Nieto-Olivares A, García-Molina F, Ricote G, Montenegro S, Sánchez-Cánovas M, Garrido-Rodríguez P, Peñas-Martínez J, Vicente V, Martínez F, Lozano ML, Carmona-Bayonas A, Martínez-Martínez I. Zaragoza-Huesca D, et al. Among authors: penas martinez j. Cancers (Basel). 2022 Jun 24;14(13):3106. doi: 10.3390/cancers14133106. Cancers (Basel). 2022. PMID: 35804878 Free PMC article.
Identification of Thrombosis-Related Genes in Patients with Advanced Gastric Cancer: Data from AGAMENON-SEOM Registry.
Zaragoza-Huesca D, Garrido-Rodríguez P, Jiménez-Fonseca P, Martínez de Castro E, Sánchez-Cánovas M, Visa L, Custodio A, Fernández-Montes A, Peñas-Martínez J, Morales Del Burgo P, Gallego J, Luengo-Gil G, Vicente V, Martínez-Martínez I, Carmona-Bayonas A. Zaragoza-Huesca D, et al. Among authors: penas martinez j. Biomedicines. 2022 Jan 11;10(1):148. doi: 10.3390/biomedicines10010148. Biomedicines. 2022. PMID: 35052827 Free PMC article.
Antithrombin is incorporated into exosomes produced by antithrombin non-expressing cells.
Luengo-Gil G, García-Andreo AB, Ortega-Sabater C, Bohdan N, Espín S, Peñas-Martínez J, Martínez-Planes E, García-Hernández Á, Vicente V, Quintanilla M, Martínez-Martínez I. Luengo-Gil G, et al. Among authors: penas martinez j. Biochimie. 2019 Oct;165:245-249. doi: 10.1016/j.biochi.2019.08.010. Epub 2019 Aug 21. Biochimie. 2019. PMID: 31445073
Qualitative and Quantitative Comparison of Plasma Exosomes from Neonates and Adults.
Peñas-Martínez J, Barrachina MN, Cuenca-Zamora EJ, Luengo-Gil G, Bravo SB, Caparrós-Pérez E, Teruel-Montoya R, Eliseo-Blanco J, Vicente V, García Á, Martínez-Martínez I, Ferrer-Marín F. Peñas-Martínez J, et al. Int J Mol Sci. 2021 Feb 15;22(4):1926. doi: 10.3390/ijms22041926. Int J Mol Sci. 2021. PMID: 33672065 Free PMC article.
Suramin, a drug for the treatment of trypanosomiasis, reduces the prothrombotic and metastatic phenotypes of colorectal cancer cells by inhibiting hepsin.
Zaragoza-Huesca D, Rodenas MC, Peñas-Martínez J, Pardo-Sánchez I, Peña-García J, Espín S, Ricote G, Nieto A, García-Molina F, Vicente V, Lozano ML, Carmona-Bayonas A, Mulero V, Pérez-Sánchez H, Martínez-Martínez I. Zaragoza-Huesca D, et al. Among authors: penas martinez j. Biomed Pharmacother. 2023 Dec;168:115814. doi: 10.1016/j.biopha.2023.115814. Epub 2023 Oct 31. Biomed Pharmacother. 2023. PMID: 37918256 Free article.