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Phormidolides B and C, cytotoxic agents from the sea: enantioselective synthesis of the macrocyclic core.
Lorente A, Gil A, Fernández R, Cuevas C, Albericio F, Álvarez M. Lorente A, et al. Chemistry. 2015 Jan 2;21(1):150-6. doi: 10.1002/chem.201404341. Epub 2014 Oct 30. Chemistry. 2015. PMID: 25359690
The key step of the synthesis is the formation of the Z-trisubstituted double bond using a Julia-Kocienski olefination. The versatility of the synthetic methodology may provide access to other enantiopure macrocycles by making changes in the starting materials or chiral in …
The key step of the synthesis is the formation of the Z-trisubstituted double bond using a Julia-Kocienski olefination. The versatili …