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Synthesis of Novel N4-Hydrocytidine Analogs as Potential Anti-SARS-CoV-2 Agents.
Amblard F, LeCher JC, De R, Goh SL, Li C, Kasthuri M, Biteau N, Zhou L, Tber Z, Downs-Bowen J, Zandi K, Schinazi RF. Amblard F, et al. Among authors: lecher jc. Pharmaceuticals (Basel). 2022 Sep 14;15(9):1144. doi: 10.3390/ph15091144. Pharmaceuticals (Basel). 2022. PMID: 36145365 Free PMC article.
Discovery of a 2'-Fluoro,2'-Bromouridine Phosphoramidate Prodrug Exhibiting Anti-Yellow Fever Virus Activity in Culture and in Mice.
LeCher JC, Zandi K, Costa VV, Amblard F, Tao S, Patel D, Lee S, da Silva Santos FR, Goncalves MR, Queroz-Junior CM, Marim FM, Musall K, Goh SL, McBrayer T, Downs-Bowen J, De R, Azadi N, Kohler J, Teixeira MM, Schinazi RF. LeCher JC, et al. Microorganisms. 2022 Oct 22;10(11):2098. doi: 10.3390/microorganisms10112098. Microorganisms. 2022. PMID: 36363688 Free PMC article.
Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside.
Tao S, Zandi K, Bassit L, Ong YT, Verma K, Liu P, Downs-Bowen JA, McBrayer T, LeCher JC, Kohler JJ, Tedbury PR, Kim B, Amblard F, Sarafianos SG, Schinazi RF. Tao S, et al. Among authors: lecher jc. Curr Res Pharmacol Drug Discov. 2021;2:100045. doi: 10.1016/j.crphar.2021.100045. Epub 2021 Aug 12. Curr Res Pharmacol Drug Discov. 2021. PMID: 34870151 Free PMC article.
Stably-Inverted Apical-Out Human Upper Airway Organoids for SARS-CoV-2 Infection and Therapeutic Testing.
Lee JH, LeCher JC, Parigoris E, Shinagawa N, Sentosa J, Manfredi C, Goh SL, De R, Tao S, Zandi K, Amblard F, Sorscher EJ, Spence JR, Tirouvanziam R, Schinazi RF, Takayama S. Lee JH, et al. Among authors: lecher jc. bioRxiv [Preprint]. 2024 Jan 4:2024.01.02.573939. doi: 10.1101/2024.01.02.573939. bioRxiv. 2024. PMID: 38260306 Free PMC article. Preprint.
Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease.
Amblard F, LeCher JC, De R, Zhou S, Liu P, Goh SL, Tao S, Patel D, Downs-Bowen J, Zandi K, Zhang H, Chaudhry G, McBrayer T, Muczynski M, Al-Homoudi A, Engel J, Lan S, Sarafianos SG, Kovari LC, Schinazi RF. Amblard F, et al. Among authors: lecher jc. Eur J Med Chem. 2024 Mar 15;268:116263. doi: 10.1016/j.ejmech.2024.116263. Epub 2024 Feb 24. Eur J Med Chem. 2024. PMID: 38432056