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The landscape of tolerated genetic variation in humans and primates.
Gao H, Hamp T, Ede J, Schraiber JG, McRae J, Singer-Berk M, Yang Y, Dietrich ASD, Fiziev PP, Kuderna LFK, Sundaram L, Wu Y, Adhikari A, Field Y, Chen C, Batzoglou S, Aguet F, Lemire G, Reimers R, Balick D, Janiak MC, Kuhlwilm M, Orkin JD, Manu S, Valenzuela A, Bergman J, Rousselle M, Silva FE, Agueda L, Blanc J, Gut M, de Vries D, Goodhead I, Harris RA, Raveendran M, Jensen A, Chuma IS, Horvath JE, Hvilsom C, Juan D, Frandsen P, de Melo FR, Bertuol F, Byrne H, Sampaio I, Farias I, do Amaral JV, Messias M, da Silva MNF, Trivedi M, Rossi R, Hrbek T, Andriaholinirina N, Rabarivola CJ, Zaramody A, Jolly CJ, Phillips-Conroy J, Wilkerson G, Abee C, Simmons JH, Fernandez-Duque E, Kanthaswamy S, Shiferaw F, Wu D, Zhou L, Shao Y, Zhang G, Keyyu JD, Knauf S, Le MD, Lizano E, Merker S, Navarro A, Bataillon T, Nadler T, Khor CC, Lee J, Tan P, Lim WK, Kitchener AC, Zinner D, Gut I, Melin A, Guschanski K, Schierup MH, Beck RMD, Umapathy G, Roos C, Boubli JP, Lek M, Sunyaev S, O'Donnell-Luria A, Rehm HL, Xu J, Rogers J, Marques-Bonet T, Farh KK. Gao H, et al. Science. 2023 Jun 2;380(6648):eabn8153. doi: 10.1126/science.abn8197. Epub 2023 Jun 2. Science. 2023. PMID: 37262156 Free PMC article.
Ophthalmic Manifestations of Hodgkin Lymphoma: A Review.
Valenzuela J, Echegaray JJ, Dodds E, Kurup SK, Lowder C, Ondrejka SL, Singh AD. Valenzuela J, et al. Ocul Oncol Pathol. 2021 Dec;7(6):381-389. doi: 10.1159/000519032. Epub 2021 Aug 17. Ocul Oncol Pathol. 2021. PMID: 35087814 Free PMC article. Review.
Identification of constrained sequence elements across 239 primate genomes.
Kuderna LFK, Ulirsch JC, Rashid S, Ameen M, Sundaram L, Hickey G, Cox AJ, Gao H, Kumar A, Aguet F, Christmas MJ, Clawson H, Haeussler M, Janiak MC, Kuhlwilm M, Orkin JD, Bataillon T, Manu S, Valenzuela A, Bergman J, Rouselle M, Silva FE, Agueda L, Blanc J, Gut M, de Vries D, Goodhead I, Harris RA, Raveendran M, Jensen A, Chuma IS, Horvath JE, Hvilsom C, Juan D, Frandsen P, Schraiber JG, de Melo FR, Bertuol F, Byrne H, Sampaio I, Farias I, Valsecchi J, Messias M, da Silva MNF, Trivedi M, Rossi R, Hrbek T, Andriaholinirina N, Rabarivola CJ, Zaramody A, Jolly CJ, Phillips-Conroy J, Wilkerson G, Abee C, Simmons JH, Fernandez-Duque E, Kanthaswamy S, Shiferaw F, Wu D, Zhou L, Shao Y, Zhang G, Keyyu JD, Knauf S, Le MD, Lizano E, Merker S, Navarro A, Nadler T, Khor CC, Lee J, Tan P, Lim WK, Kitchener AC, Zinner D, Gut I, Melin AD, Guschanski K, Schierup MH, Beck RMD, Karakikes I, Wang KC, Umapathy G, Roos C, Boubli JP, Siepel A, Kundaje A, Paten B, Lindblad-Toh K, Rogers J, Marques Bonet T, Farh KK. Kuderna LFK, et al. Nature. 2024 Jan;625(7996):735-742. doi: 10.1038/s41586-023-06798-8. Epub 2023 Nov 29. Nature. 2024. PMID: 38030727 Free PMC article.
coMpliAnce with evideNce-based cliniCal guidelines in the managemenT of acute biliaRy pancreAtitis): The MANCTRA-1 international audit.
Podda M, Pacella D, Pellino G, Coccolini F, Giordano A, Di Saverio S, Pata F, Ielpo B, Virdis F, Damaskos D, De Simone B, Agresta F, Sartelli M, Leppaniemi A, Riboni C, Agnoletti V, Mole D, Kluger Y, Catena F, Pisanu A; MANCTRA-1 Collaborative Group; Principal Investigator; Steering Committee; MANCTRA-1 Coordinating Group; Local Collaborators; Argentina; Australia; Bahrain; Brazil; Bulgaria; China; Colombia; Czech Republic; Egypt; France; Georgia; Greece; Guatemala; India; Italy; Jordan; Malaysia; Mexico; Nigeria; Pakistan; Paraguay; Peru; Philippines; Poland; Portugal; Qatar; Romania; Russia; Serbia; Slovak Republic; South Africa; Spain; Sudan; Switzerland; Syria; Tunisia; Turkey; United Kingdom; Uruguay; Yemen. Podda M, et al. Pancreatology. 2022 Nov;22(7):902-916. doi: 10.1016/j.pan.2022.07.007. Epub 2022 Jul 16. Pancreatology. 2022. PMID: 35963665 Free article.
Commentaries on Viewpoint: Physiology and fast marathons.
Santos-Concejero J, González-Mohíno F, González-Ravé JM, Perrey S, Dewolf AH, Yates BA, Ušaj A, Debevec T, González-Rayas JM, Rayas-Gómez AL, González-Yáñez JM, Lepers R, Stapley P, Louis J, Proessl F, Nikolaidis PT, Knechtle B, Muniz-Pumares D, Hunter B, Bottoms L, Bontemps B, Valenzuela PL, Boullosa D, Del Coso J, Blagrove RC, Hayes PR, Millet GP, Malatesta D, de Almeida Costa Campos Y, Pereira Guimarães M, Macedo Vianna J, Fernandes da Silva S, Silva Marques de Azevedo PH, Paris HL, Leist MA, Lige MT, Malysa W, Oumsang AS, Sinai EC, Hansen RK, Secher NH, Volianitis S, Hottenrott L, Hottenrott K, Gronwald T, Senefeld JW, Fernandes RJ, Vilas-Boas JP, Riveros-Rivera A, Böning D, Craighead DH, Kipp S, Kram R, Zinner C, Sperlich B, Holmberg HC, Muniz-Pardos B, Sutehall S, Angeloudis K, Guppy FM, Bosch A, Pitsiladis Y, Andrade DC, Del Rio R, Ramirez-Campillo R, Lopes TR, Silva BM, Ives SJ, Weyand PG, Brietzke C, Franco-Alvarenga PE, Meireles dos Santos T, Pires FO, Layec G, Hoogkamer W, Balestrini CS, Goss CS, Gabler MC, Escalera A, Bielko SA, Chapman RF. Santos-Concejero J, et al. J Appl Physiol (1985). 2020 Apr 1;128(4):1069-1085. doi: 10.1152/japplphysiol.00167.2020. J Appl Physiol (1985). 2020. PMID: 32293919 Free article. No abstract available.
Population pharmacokinetics meta-analysis of plitidepsin (Aplidin) in cancer subjects.
Nalda-Molina R, Valenzuela B, Ramon-Lopez A, Miguel-Lillo B, Soto-Matos A, Perez-Ruixo JJ. Nalda-Molina R, et al. Cancer Chemother Pharmacol. 2009 Jun;64(1):97-108. doi: 10.1007/s00280-008-0841-4. Epub 2008 Oct 22. Cancer Chemother Pharmacol. 2009. PMID: 18941750
RESULTS: Plasma clearance and its between subject variability (%) was 13.6 l/h (71). Volume of distribution at steady-state was calculated to be 4791 l (59). The parameters B (max) and C (50) of the non-linear blood distribution were 471 microg/l (56) and 41. …
RESULTS: Plasma clearance and its between subject variability (%) was 13.6 l/h (71). Volume of distribution at steady-state was calcu …
Development of a copro-LAMP assay for detection of several species of Echinococcus granulosus sensu lato complex.
Avila HG, Mozzoni C, Trangoni MD, Cravero SLP, Pérez VM, Valenzuela F, Gertiser ML, Butti MJ, Kamenetzky L, Jensen O, Rosenzvit MC. Avila HG, et al. Vet Parasitol. 2020 Jan;277:109017. doi: 10.1016/j.vetpar.2019.109017. Epub 2019 Dec 23. Vet Parasitol. 2020. PMID: 31901535
The etiological agent is the complex Echinococcus granulosus sensu lato (s. l.), composed of several species/genotypes. Diagnosis in the definitive host and molecular epidemiology studies are important points for cystic echinococcosis control. ...
The etiological agent is the complex Echinococcus granulosus sensu lato (s. l.), composed of several species/genotypes. Diagnosis in …
Stabilization of potentially toxic elements contained in mine waste: A microbiological approach for the environmental management of mine tailings.
Valenzuela EI, García-Figueroa AC, Amábilis-Sosa LE, Molina-Freaner FE, Pat-Espadas AM. Valenzuela EI, et al. J Environ Manage. 2020 Sep 15;270:110873. doi: 10.1016/j.jenvman.2020.110873. Epub 2020 Jun 5. J Environ Manage. 2020. PMID: 32721316
Major TIR's were found to be the triggering factor for the highest SR activities observed (73.6 8.8 mg SO(4)(2-) L(-1) day(-1)). This stimulation was linked to the dissolution of sulfate bearing minerals (anglesite, jarosite, and gypsum) which provided additional sulfate f …
Major TIR's were found to be the triggering factor for the highest SR activities observed (73.6 8.8 mg SO(4)(2-) L(-1) day(-1)). This …
Semi-mechanistic model for neutropenia after high dose of chemotherapy in breast cancer patients.
Ramon-Lopez A, Nalda-Molina R, Valenzuela B, Perez-Ruixo JJ. Ramon-Lopez A, et al. Pharm Res. 2009 Aug;26(8):1952-62. doi: 10.1007/s11095-009-9910-6. Epub 2009 Jun 2. Pharm Res. 2009. PMID: 19488837
RESULTS: The typical of the ANC at baseline (Circ(0)), mean transit time (MTT), feedback parameter (gamma), k(in) and alpha were estimated to be 5,610 x 10(6)/L, 3.25 days, 0.145, 0.954 cell/kg/day and 2.50 h/U, respectively. rHuG-CSF shortens the MTT by 92% and increases …
RESULTS: The typical of the ANC at baseline (Circ(0)), mean transit time (MTT), feedback parameter (gamma), k(in) and alpha were estimated t …