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The role of molecular pathology in mediastinal sarcomas.
Suster DI. Suster DI. Mediastinum. 2020 Dec 30;4:33. doi: 10.21037/med-20-39. eCollection 2020. Mediastinum. 2020. PMID: 35118301 Free PMC article. Review.
Many of these sarcomas have specific, recurrent genetic abnormalities that can be identified through cytogenetic and molecular testing allowing for accurate diagnosis. This review aims to cover the role of molecular pathology, specifically with regards to dia …
Many of these sarcomas have specific, recurrent genetic abnormalities that can be identified through cytogenetic and molecular testin …
The Journal of Molecular Diagnostics: 20 Years of Clinical Innovation.
O'Leary TJ. O'Leary TJ. J Mol Diagn. 2019 Nov;21(6):935-937. doi: 10.1016/j.jmoldx.2019.09.002. J Mol Diagn. 2019. PMID: 31635796 Free article.
This guest editorial highlights 20 years of clinical innovation in JMD....
This guest editorial highlights 20 years of clinical innovation in JMD....
Pathology of thymoma-where are we today?
Soomro IN. Soomro IN. J Thorac Dis. 2020 Dec;12(12):7545-7552. doi: 10.21037/jtd-2019-thym-04. J Thorac Dis. 2020. PMID: 33447445 Free PMC article. Review.
Inspite of this there are advances in understanding the pathology of thymic epithelial neoplasms including genetics, PD-L1 and molecular testing which has bearing on the prognosis, post-surgical management, and testing algorithm. Similar to pulmonary pathology …
Inspite of this there are advances in understanding the pathology of thymic epithelial neoplasms including genetics, PD-L1 and mol …
Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion.
Battistello E, Hixon KA, Comstock DE, Collings CK, Chen X, Rodriguez Hernaez J, Lee S, Cervantes KS, Hinkley MM, Ntatsoulis K, Cesarano A, Hockemeyer K, Haining WN, Witkowski MT, Qi J, Tsirigos A, Perna F, Aifantis I, Kadoch C. Battistello E, et al. Mol Cell. 2023 Apr 20;83(8):1216-1236.e12. doi: 10.1016/j.molcel.2023.02.026. Epub 2023 Mar 20. Mol Cell. 2023. PMID: 36944333 Free PMC article.
Is the diagnostic yield of mediastinal lymph node cryobiopsy (cryoEBUS) better for diagnosing mediastinal node involvement compared to endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)? A systematic review.
Botana-Rial M, Lojo-Rodríguez I, Leiro-Fernández V, Ramos-Hernández C, González-Montaos A, Pazos-Area L, Núñez-Delgado M, Fernández-Villar A. Botana-Rial M, et al. Respir Med. 2023 Nov;218:107389. doi: 10.1016/j.rmed.2023.107389. Epub 2023 Aug 12. Respir Med. 2023. PMID: 37579981 Review.
In addition, it seems that the samples obtained by cryoEBUS better defined the histological subtypes of lymphoma and allowed complete molecular characterisation in cases of lung cancer. The technique has proven to be safe and no serious complications were described after t …
In addition, it seems that the samples obtained by cryoEBUS better defined the histological subtypes of lymphoma and allowed complete mol …
Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease.
Baloni P, Arnold M, Buitrago L, Nho K, Moreno H, Huynh K, Brauner B, Louie G, Kueider-Paisley A, Suhre K, Saykin AJ, Ekroos K, Meikle PJ, Hood L, Price ND; Alzheimer’s Disease Metabolomics Consortium; Doraiswamy PM, Funk CC, Hernández AI, Kastenmüller G, Baillie R, Han X, Kaddurah-Daouk R. Baloni P, et al. Commun Biol. 2022 Oct 8;5(1):1074. doi: 10.1038/s42003-022-04011-6. Commun Biol. 2022. PMID: 36209301 Free PMC article.
Genome-wide and transcriptome-wide association studies have identified various genes and genetic variants in lipid metabolism that are associated with Alzheimer's disease. However, the molecular mechanisms of sphingomyelin and ceramide disruption remain to be determined. . …
Genome-wide and transcriptome-wide association studies have identified various genes and genetic variants in lipid metabolism that are assoc …
Editor Profile: Manuela Baccarini.
FEBS Journal Editorial Team; Baccarini M. FEBS Journal Editorial Team, et al. FEBS J. 2023 Jan;290(1):73-75. doi: 10.1111/febs.16423. Epub 2022 Mar 25. FEBS J. 2023. PMID: 35332671 Free article.
In this special interview series, we profile members of The FEBS Journal editorial board to highlight their research focus, perspectives on the journal and future directions in their field. ...She has served as an editorial board member of The FEBS …
In this special interview series, we profile members of The FEBS Journal editorial board to highlight their research focus, pe …
Liposarcomas of the mediastinum.
Suster DI, Suster S. Suster DI, et al. Mediastinum. 2020 Sep 30;4:27. doi: 10.21037/med-20-42. eCollection 2020. Mediastinum. 2020. PMID: 35118295 Free PMC article. Review.
MDM2 and CDK4 amplification can be assessed by immunohistochemistry, fluorescence in situ hybridization, or molecular techniques that evaluate copy number alterations and amplifications such as array based assays and next generation sequencing (NGS). ...
MDM2 and CDK4 amplification can be assessed by immunohistochemistry, fluorescence in situ hybridization, or molecular techniques that …
Primary mediastinal synovial sarcomas.
Syred K, Weissferdt A. Syred K, et al. Mediastinum. 2020 Jun 30;4:13. doi: 10.21037/med-20-19. eCollection 2020. Mediastinum. 2020. PMID: 35118281 Free PMC article. Review.
Histologically, these tumors can be divided into monophasic, biphasic and poorly differentiated variants, further complicating the diagnostic process. Recent advances in immunohistochemical and molecular techniques have provided useful tools to confirm the diagnosis and di …
Histologically, these tumors can be divided into monophasic, biphasic and poorly differentiated variants, further complicating the diagnosti …
GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors.
Docherty AR, Mullins N, Ashley-Koch AE, Qin X, Coleman JRI, Shabalin A, Kang J, Murnyak B, Wendt F, Adams M, Campos AI, DiBlasi E, Fullerton JM, Kranzler HR, Bakian AV, Monson ET, Rentería ME, Walss-Bass C, Andreassen OA, Behera C, Bulik CM, Edenberg HJ, Kessler RC, Mann JJ, Nurnberger JI Jr, Pistis G, Streit F, Ursano RJ, Polimanti R, Dennis M, Garrett M, Hair L, Harvey P, Hauser ER, Hauser MA, Huffman J, Jacobson D, Madduri R, McMahon B, Oslin DW, Trafton J, Awasthi S, Berrettini WH, Bohus M, Chang X, Chen HC, Chen WJ, Christensen ED, Crow S, Duriez P, Edwards AC, Fernández-Aranda F, Galfalvy H, Gandal M, Gorwood P, Guo Y, Hafferty JD, Hakonarson H, Halmi KA, Hishimoto A, Jain S, Jamain S, Jiménez-Murcia S, Johnson C, Kaplan AS, Kaye WH, Keel PK, Kennedy JL, Kim M, Klump KL, Levey DF, Li D, Liao SC, Lieb K, Lilenfeld L, Marshall CR, Mitchell JE, Okazaki S, Otsuka I, Pinto D, Powers A, Ramoz N, Ripke S, Roepke S, Rozanov V, Scherer SW, Schmahl C, Sokolowski M, Starnawska A, Strober M, Su MH, Thornton LM, Treasure J, Ware EB, Watson HJ, Witt SH, Woodside DB, Yilmaz Z, Zillich L, Adolfsson R, Agartz I, Alda M, Alfredsson L, Appadurai V, Artigas MS, Van der Auwera S, Azevedo MH, Bas… See abstract for full author list ➔ Docherty AR, et al. Am J Psychiatry. 2023 Oct 1;180(10):723-738. doi: 10.1176/appi.ajp.21121266. Am J Psychiatry. 2023. PMID: 37777856 Free PMC article.
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