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The γ-Benzylidene Digoxin Derivative BD-15 Increases the α3-Na, K-ATPase Activity in Rat Hippocampus and Prefrontal Cortex and no Change on Heart.
Parreira GM, Faria JA, Marques SMS, Garcia IJP, Silva IF, De Carvalho LED, Villar JAFP, Machado MV, de Castro Lima M, Barbosa LA, Cortes VF, de Lima Santos H. Parreira GM, et al. Among authors: villar jafp. J Membr Biol. 2021 Apr;254(2):189-199. doi: 10.1007/s00232-021-00173-2. Epub 2021 Feb 18. J Membr Biol. 2021. PMID: 33598793
Rational selection of immunodominant and preserved epitope Sm043300e from Schistosoma mansoni and design of a chimeric molecule for biotechnological purposes.
de Souza C, Lopes MD, De Oliveira FM, Passos MJF, Ferreira LCG, Faria BF, Villar JAFP, Junior MC, Taranto AG, Dos Santos LL, Fonseca CT, de Oliveira Lopes D. de Souza C, et al. Among authors: villar jafp. Mol Immunol. 2018 Jan;93:133-143. doi: 10.1016/j.molimm.2017.11.019. Epub 2017 Nov 22. Mol Immunol. 2018. PMID: 29175593
21‑Benzylidene digoxin, a novel digoxin hemi-synthetic derivative, presents an anti-inflammatory activity through inhibition of edema, tumour necrosis factor alpha production, inducible nitric oxide synthase expression and leucocyte migration.
Vieira L, Saldanha AA, Moraes AM, Oliveira FM, Lopes DO, Barbosa LAO, Ribeiro RIMA, Thomé RG, Santos HBD, Villar JAFP, Soares AC. Vieira L, et al. Among authors: villar jafp. Int Immunopharmacol. 2018 Dec;65:174-181. doi: 10.1016/j.intimp.2018.10.010. Epub 2018 Oct 10. Int Immunopharmacol. 2018. PMID: 30316075 Free article.
Synthesis and biological evaluation of novel 3-alkylpyridine marine alkaloid analogs with promising anticancer activity.
Gonçalves AM, de Lima AB, da Silva Barbosa MC, de Camargos LF, de Oliveira JT, de Souza Barbosa C, Villar JA, Costa AC, Silva IV, Silva LM, de Pilla Varotti F, dos Santos FV, Viana GH. Gonçalves AM, et al. Among authors: villar ja. Mar Drugs. 2014 Jul 31;12(8):4361-78. doi: 10.3390/md12084361. Mar Drugs. 2014. PMID: 25089949 Free PMC article.