Photodynamic Therapy With Methylene Blue for Skin Ulcers Infected With Pseudomonas aeruginosa and Fusarium spp
Actas Dermosifiliogr. 2017 Jul-Aug;108(6):e45-e48.
doi: 10.1016/j.ad.2016.11.020.
Epub 2017 Apr 13.
[Article in
English,
Spanish]
Affiliations
- 1 Sección de Microbiología, Hospital Royo Villanova, Zaragoza, España. Electronic address: caspirozs@gmail.com.
- 2 Servicio de Medicina Interna, Hospital Royo Villanova, Zaragoza, España.
- 3 Servicio de Medicina Interna/Unidad de Enfermedades Infecciosas, Hospital Royo Villanova, Zaragoza, España.
- 4 Servicio de Dermatología, Hospital San Jorge, Huesca, España; Instituto Aragonés de Ciencias de la Salud, Zaragoza, España.
Abstract
Photodynamic therapy (PDT) is a therapeutic modality with significant antimicrobial activity. We present 2 cases of chronic lower limb ulcers in which fungal and bacterial superinfection complicated management. PDT with methylene blue as the photosensitizer led to clinical and microbiological cure with no significant adverse effects. PDT with methylene blue is a valid option for the management of superinfected chronic ulcers, reducing the use of antibiotics and the induction of resistance.
Keywords:
Azul de metileno; Fusarium spp.; Methylene blue; Photodynamic therapy; Pseudomonas aeruginosa; Terapia fotodinámica; Ulcers; Úlceras.
Copyright © 2017 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.
MeSH terms
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Adult
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Aged
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Burns, Electric / complications
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Burns, Electric / microbiology
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Chronic Disease
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Female
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Fusariosis / drug therapy*
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Fusariosis / etiology
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Fusarium / drug effects*
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Humans
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Immunocompromised Host
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Intraoperative Complications
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Leg Ulcer / complications
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Leg Ulcer / microbiology*
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Methylene Blue / therapeutic use*
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Mycoses / drug therapy*
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Mycoses / etiology
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Photochemotherapy*
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Photosensitizing Agents / therapeutic use*
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Pseudomonas Infections / drug therapy*
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Pseudomonas Infections / etiology
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Pseudomonas aeruginosa / drug effects*
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Superinfection / drug therapy*
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Superinfection / etiology
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Wound Healing
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Wound Infection / drug therapy
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Wound Infection / microbiology
Substances
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Photosensitizing Agents
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Methylene Blue