Synthetic approaches and pharmacological activity of 1,3,4-oxadiazoles: a review of the literature from 2000-2012

Cledualdo Soares de Oliveira; Bruno Freitas Lira; José Maria Barbosa-Filho; Jorge Gonçalo Fernandez Lorenzo; Petrônio Filgueiras de Athayde-Filho

doi:10.3390/molecules170910192

Synthetic approaches and pharmacological activity of 1,3,4-oxadiazoles: a review of the literature from 2000-2012

Molecules. 2012 Aug 27;17(9):10192-231. doi: 10.3390/molecules170910192.

Authors

Cledualdo Soares de Oliveira¹, Bruno Freitas Lira, José Maria Barbosa-Filho, Jorge Gonçalo Fernandez Lorenzo, Petrônio Filgueiras de Athayde-Filho

Affiliation

¹ Department of Chemistry, Federal University of Paraíba, 58051-900 João Pessoa-PB, Brazil.

Abstract

This review provides readers with an overview of the main synthetic methodologies for 1,3,4-oxadiazole derivatives, and of their broad spectrum of pharmacological activities as reported over the past twelve years.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal / chemistry
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Antifungal Agents / chemical synthesis
Antifungal Agents / chemistry
Antifungal Agents / pharmacology
Oxadiazoles / chemical synthesis*
Oxadiazoles / chemistry
Oxadiazoles / pharmacology*
Pyrrolidines / chemistry
Pyrrolidines / pharmacology
Pyrrolidines / therapeutic use
Pyrrolidinones / chemistry
Pyrrolidinones / pharmacology
Pyrrolidinones / therapeutic use
Raltegravir Potassium

Substances

Anti-Bacterial Agents
Anti-Inflammatory Agents, Non-Steroidal
Antifungal Agents
Oxadiazoles
Pyrrolidines
Pyrrolidinones
ZD4054
Raltegravir Potassium