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Mitochondrial leak metabolism induces the Spemann-Mangold Organizer via Hif-1alpha in Xenopus.
MacColl Garfinkel A, Mnatsakanyan N, Patel JH, Wills AE, Shteyman A, Smith PJS, Alavian KN, Jonas EA, Khokha MK. MacColl Garfinkel A, et al. Dev Cell. 2023 Nov 20;58(22):2597-2613.e4. doi: 10.1016/j.devcel.2023.08.015. Epub 2023 Sep 5. Dev Cell. 2023. PMID: 37673063
We demonstrate that mitochondrial oxidative metabolism establishes the embryonic patterning center, the Spemann-Mangold Organizer, via hypoxia-inducible factor 1alpha (Hif-1alpha) in Xenopus. ...
We demonstrate that mitochondrial oxidative metabolism establishes the embryonic patterning center, the Spemann-Mangold Organizer, vi …