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Page 1
Rational optimization of a transcription factor activation domain inhibitor.
Nat Struct Mol Biol. 2023 Dec;30(12):1958-1969. doi: 10.1038/s41594-023-01159-5. Epub 2023 Dec 4.
Nat Struct Mol Biol. 2023.
PMID: 38049566
Free PMC article.
Differential Gene Expression Profiles between N-Terminal Domain and Ligand-Binding Domain Inhibitors of Androgen Receptor Reveal Ralaniten Induction of Metallothionein by a Mechanism Dependent on MTF1.
Obst JK, Mawji NR, Teskey SJL, Wang J, Sadar MD.
Obst JK, et al.
Cancers (Basel). 2022 Jan 13;14(2):386. doi: 10.3390/cancers14020386.
Cancers (Basel). 2022.
PMID: 35053548
Free PMC article.
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Revealing Metabolic Liabilities of Ralaniten To Enhance Novel Androgen Receptor Targeted Therapies.
Obst JK, Wang J, Jian K, Williams DE, Tien AH, Mawji N, Tam T, Yang YC, Andersen RJ, Chi KN, Montgomery B, Sadar MD.
Obst JK, et al.
ACS Pharmacol Transl Sci. 2019 Sep 26;2(6):453-467. doi: 10.1021/acsptsci.9b00065. eCollection 2019 Dec 13.
ACS Pharmacol Transl Sci. 2019.
PMID: 32259077
Free PMC article.
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Ralaniten Sensitizes Enzalutamide-Resistant Prostate Cancer to Ionizing Radiation in Prostate Cancer Cells that Express Androgen Receptor Splice Variants.
Banuelos CA, Ito Y, Obst JK, Mawji NR, Wang J, Hirayama Y, Leung JK, Tam T, Tien AH, Andersen RJ, Sadar MD.
Banuelos CA, et al. Among authors: obst jk.
Cancers (Basel). 2020 Jul 21;12(7):1991. doi: 10.3390/cancers12071991.
Cancers (Basel). 2020.
PMID: 32708219
Free PMC article.
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Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation.
Obst JK, Sadar MD.
Obst JK, et al.
Transl Cancer Res. 2016 Sep;5(Suppl 3):S529-S531. doi: 10.21037/tcr.2016.07.35.
Transl Cancer Res. 2016.
PMID: 30815377
Free PMC article.
No abstract available.
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