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Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress and induces caspase-dependent cell death in antiestrogen-sensitive and resistant ER+ breast cancer cells.
Periyasamy-Thandavan S, Jackson WH, Samaddar JS, Erickson B, Barrett JR, Raney L, Gopal E, Ganapathy V, Hill WD, Bhalla KN, Schoenlein PV. Periyasamy-Thandavan S, et al. Among authors: barrett jr. Autophagy. 2010 Jan;6(1):19-35. doi: 10.4161/auto.6.1.10323. Autophagy. 2010. PMID: 20110775
Rapamycin up-regulation of autophagy reduces infarct size and improves outcomes in both permanent MCAL, and embolic MCAO, murine models of stroke.
Buckley KM, Hess DL, Sazonova IY, Periyasamy-Thandavan S, Barrett JR, Kirks R, Grace H, Kondrikova G, Johnson MH, Hess DC, Schoenlein PV, Hoda MN, Hill WD. Buckley KM, et al. Among authors: barrett jr. Exp Transl Stroke Med. 2014 Jun 21;6:8. doi: 10.1186/2040-7378-6-8. eCollection 2014. Exp Transl Stroke Med. 2014. PMID: 24991402 Free PMC article.