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Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on celecoxib scaffold supported with in vivo anti-inflammatory activity, ulcerogenic liability, ADME profiling and docking study.
Abdellatif KRA, Abdelall EKA, Elshemy HAH, Philoppes JN, Hassanein EHM, Kahk NM. Abdellatif KRA, et al. Among authors: philoppes jn. Bioorg Chem. 2022 Mar;120:105627. doi: 10.1016/j.bioorg.2022.105627. Epub 2022 Jan 19. Bioorg Chem. 2022. PMID: 35065465
Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and molecular modeling studies.
Abdellatif KRA, Abdelall EKA, Elshemy HAH, Philoppes JN, Hassanein EHM, Kahk NM. Abdellatif KRA, et al. Among authors: philoppes jn. Bioorg Chem. 2021 Sep;114:105122. doi: 10.1016/j.bioorg.2021.105122. Epub 2021 Jun 25. Bioorg Chem. 2021. PMID: 34243075
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