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Table representation of search results timeline featuring number of search results per year.
Year | Number of Results |
---|---|
2000 | 1 |
2001 | 1 |
2004 | 2 |
2007 | 1 |
2009 | 1 |
2010 | 2 |
2011 | 2 |
2013 | 1 |
2014 | 8 |
2015 | 20 |
2016 | 25 |
2017 | 17 |
2018 | 16 |
2019 | 28 |
2020 | 29 |
2021 | 33 |
2022 | 40 |
2023 | 34 |
2024 | 10 |
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Of these, 41 had one of five known pathogenic POLE exonuclease domain mutations (EDM) and showed characteristic genomic alterations: C>A substitution > 20%, T>G substitutions > 4%, C>G substitutions < 0.6%, indels < 5%, TMB > 100 mut/Mb. ...T
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