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Page 1
Targeting viral genome synthesis as broad-spectrum approach against RNA virus infections.
Antivir Chem Chemother. 2020 Jan-Dec;28:2040206620976786. doi: 10.1177/2040206620976786.
Antivir Chem Chemother. 2020.
PMID: 33297724
Free PMC article.
Review.
Synthesis of T-705-Ribonucleoside and T-705-Ribonucleotide and Studies of Chemical Stability.
Huchting J, Winkler M, Nasser H, Meier C.
Huchting J, et al.
ChemMedChem. 2017 May 9;12(9):652-659. doi: 10.1002/cmdc.201700116. Epub 2017 Mar 31.
ChemMedChem. 2017.
PMID: 28324644
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Cell line-dependent activation and antiviral activity of T-1105, the non-fluorinated analogue of T-705 (favipiravir).
Huchting J, Vanderlinden E, Van Berwaer R, Meier C, Naesens L.
Huchting J, et al.
Antiviral Res. 2019 Jul;167:1-5. doi: 10.1016/j.antiviral.2019.04.002. Epub 2019 Apr 2.
Antiviral Res. 2019.
PMID: 30951731
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Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Kouba T, Dubankova A, Drncova P, Donati E, Vidossich P, Speranzini V, Pflug A, Huchting J, Meier C, De Vivo M, Cusack S.
Kouba T, et al. Among authors: huchting j.
Cell Rep. 2023 Jan 31;42(1):111901. doi: 10.1016/j.celrep.2022.111901. Epub 2023 Jan 2.
Cell Rep. 2023.
PMID: 36596301
Free article.
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Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis.
Shannon A, Selisko B, Le NT, Huchting J, Touret F, Piorkowski G, Fattorini V, Ferron F, Decroly E, Meier C, Coutard B, Peersen O, Canard B.
Shannon A, et al. Among authors: huchting j.
Nat Commun. 2020 Sep 17;11(1):4682. doi: 10.1038/s41467-020-18463-z.
Nat Commun. 2020.
PMID: 32943628
Free PMC article.
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T-705-Derived Prodrugs Show High Antiviral Efficacies against a Broad Range of Influenza A Viruses with Synergistic Effects When Combined with Oseltamivir.
Ganter B, Zickler M, Huchting J, Winkler M, Lüttjohann A, Meier C, Gabriel G, Beck S.
Ganter B, et al. Among authors: huchting j.
Pharmaceutics. 2023 Jun 14;15(6):1732. doi: 10.3390/pharmaceutics15061732.
Pharmaceutics. 2023.
PMID: 37376180
Free PMC article.
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Prodrugs of the Phosphoribosylated Forms of Hydroxypyrazinecarboxamide Pseudobase T-705 and Its De-Fluoro Analogue T-1105 as Potent Influenza Virus Inhibitors.
Huchting J, Vanderlinden E, Winkler M, Nasser H, Naesens L, Meier C.
Huchting J, et al.
J Med Chem. 2018 Jul 26;61(14):6193-6210. doi: 10.1021/acs.jmedchem.8b00617. Epub 2018 Jul 3.
J Med Chem. 2018.
PMID: 29906392
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