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Year Number of Results
1997 1
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2014 2
2015 5
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2017 3
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2020 1
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2023 2
2024 1

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Page 1
TRPC5 Does Not Cause or Aggravate Glomerular Disease.
Wang X, Dande RR, Yu H, Samelko B, Miller RE, Altintas MM, Reiser J. Wang X, et al. J Am Soc Nephrol. 2018 Feb;29(2):409-415. doi: 10.1681/ASN.2017060682. Epub 2017 Oct 23. J Am Soc Nephrol. 2018. PMID: 29061651 Free PMC article.
To address this gap, we developed two transgenic mouse models on the C57BL/6 background by overexpressing either wild-type TRPC5 or a TRPC5 ion-pore mutant. Compared with nontransgenic controls, neither transgenic model exhibited an increase in proteinuria at 8 months of a …
To address this gap, we developed two transgenic mouse models on the C57BL/6 background by overexpressing either wild-type TRPC5 or a …
Neonatal islets from human PD-L1 transgenic pigs reduce immune cell activation and cellular rejection in humanized nonobese diabetic-scid IL2rγnull mice.
Lei Y, Wolf-van Buerck L, Honarpisheh M, Zhang Y, Schwinzer R, Petersen B, Seissler J. Lei Y, et al. Am J Transplant. 2024 Jan;24(1):20-29. doi: 10.1016/j.ajt.2023.08.026. Epub 2023 Aug 31. Am J Transplant. 2024. PMID: 37659605 Free article.
Neonatal islet-like clusters (NPICCs) from transgenic hPD-L1 (hPD-L1-Tg) and wild-type (Wt) pigs were transplanted into nonobese diabetic-scid IL2rgamma(null) mice stably reconstituted with human immune cells (hPD-L1 n = 10; Wt n = 6). ...
Neonatal islet-like clusters (NPICCs) from transgenic hPD-L1 (hPD-L1-Tg) and wild-type (Wt) pigs were transplanted into nonobese diab …
Binding of gephyrin to microtubules is regulated by its phosphorylation at Ser270.
Zhou L, Kiss E, Demmig R, Kirsch J, Nawrotzki RA, Kuhse J. Zhou L, et al. Histochem Cell Biol. 2021 Jul;156(1):5-18. doi: 10.1007/s00418-021-01973-2. Epub 2021 Apr 1. Histochem Cell Biol. 2021. PMID: 33796945 Free PMC article.
Moreover, after collybistin fostered phosphorylation at Ser270 the binding of a recombinant gephyrin to MTs was strongly reduced in co-sedimentation assays. Correspondingly, upon substitution of wild-type gephyrin with recombinant gephyrin carrying alanine mutations at put …
Moreover, after collybistin fostered phosphorylation at Ser270 the binding of a recombinant gephyrin to MTs was strongly reduced in co-sedim …
Synaptopodin Limits TRPC6 Podocyte Surface Expression and Attenuates Proteinuria.
Yu H, Kistler A, Faridi MH, Meyer JO, Tryniszewska B, Mehta D, Yue L, Dryer S, Reiser J. Yu H, et al. J Am Soc Nephrol. 2016 Nov;27(11):3308-3319. doi: 10.1681/ASN.2015080896. Epub 2016 Mar 28. J Am Soc Nephrol. 2016. PMID: 27020855 Free PMC article.
Gain-of-function mutations of classic transient receptor potential channel 6 (TRPC6) were identified in familial FSGS, and increased expression of wild-type TRPC6 in glomeruli is observed in several human acquired proteinuric diseases. ...Administration of cyclosporin A, w …
Gain-of-function mutations of classic transient receptor potential channel 6 (TRPC6) were identified in familial FSGS, and increased express …
A defined anthocyanin mixture sourced from bilberry and black currant inhibits Measles virus and various herpesviruses.
Sivarajan R, Oberwinkler H, Roll V, König EM, Steinke M, Bodem J. Sivarajan R, et al. BMC Complement Med Ther. 2022 Jul 8;22(1):181. doi: 10.1186/s12906-022-03661-7. BMC Complement Med Ther. 2022. PMID: 35804339 Free PMC article.
Then, we analysed the number of infected cells and viral infectivity and compared the data to non-treated controls. RESULTS: The BC/BL extract inhibited wild-type Measles virus replication, syncytia formation and cell-to-cell spread. This suppression was dependent on the …
Then, we analysed the number of infected cells and viral infectivity and compared the data to non-treated controls. RESULTS: The BC/BL extra …
Seeding and transgenic overexpression of alpha-synuclein triggers dendritic spine pathology in the neocortex.
Blumenstock S, Rodrigues EF, Peters F, Blazquez-Llorca L, Schmidt F, Giese A, Herms J. Blumenstock S, et al. EMBO Mol Med. 2017 May;9(5):716-731. doi: 10.15252/emmm.201607305. EMBO Mol Med. 2017. PMID: 28351932 Free PMC article.
Long-term in vivo imaging of apical dendrites was performed in mice overexpressing wild-type human alpha-synuclein. Additionally, intracranial injection of preformed alpha-synuclein fibrils was performed to induce cortical alpha-syn pathology. ...
Long-term in vivo imaging of apical dendrites was performed in mice overexpressing wild-type human alpha-synuclein. Additionally, int …
Early defects in translation elongation factor 1α levels at excitatory synapses in α-synucleinopathy.
Blumenstock S, Angelo MF, Peters F, Dorostkar MM, Ruf VC, Luckner M, Crux S, Slapakova L, Arzberger T, Claverol S, Herzog E, Herms J. Blumenstock S, et al. Acta Neuropathol. 2019 Dec;138(6):971-986. doi: 10.1007/s00401-019-02063-3. Epub 2019 Aug 26. Acta Neuropathol. 2019. PMID: 31451907
Using fluorescence-activated synaptosome sorting (FASS), we enriched excitatory glutamatergic synaptosomes from mice overexpressing human alpha-synuclein (h-alphaS) and wild-type littermates to unprecedented purity. Subsequent label-free proteomic quantification revealed a …
Using fluorescence-activated synaptosome sorting (FASS), we enriched excitatory glutamatergic synaptosomes from mice overexpressing human al …
Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity.
Kumar S, Wirths O, Stüber K, Wunderlich P, Koch P, Theil S, Rezaei-Ghaleh N, Zweckstetter M, Bayer TA, Brüstle O, Thal DR, Walter J. Kumar S, et al. Acta Neuropathol. 2016 Apr;131(4):525-37. doi: 10.1007/s00401-016-1546-0. Epub 2016 Feb 22. Acta Neuropathol. 2016. PMID: 26898910 Free PMC article.
While some rare mutations in the Abeta sequence that cause early-onset AD promote the oligomerization, molecular mechanisms that induce the formation or stabilization of oligomers of the wild-type Abeta remain unclear. Here, we identified an Abeta variant phosphorylated at …
While some rare mutations in the Abeta sequence that cause early-onset AD promote the oligomerization, molecular mechanisms that induce the …
The disorganized visual cortex in reelin-deficient mice is functional and allows for enhanced plasticity.
Pielecka-Fortuna J, Wagener RJ, Martens AK, Goetze B, Schmidt KF, Staiger JF, Löwel S. Pielecka-Fortuna J, et al. Brain Struct Funct. 2015 Nov;220(6):3449-67. doi: 10.1007/s00429-014-0866-x. Epub 2014 Aug 15. Brain Struct Funct. 2015. PMID: 25119525 Free PMC article.
We investigated the structure, function and plasticity of primary visual cortex (V1) of adult mice deficient for the glycoprotein reelin and their wild-type littermates. In V1 of rl-/- mice, cells with different laminar fates are present at all cortical depths. ...Addition …
We investigated the structure, function and plasticity of primary visual cortex (V1) of adult mice deficient for the glycoprotein reelin and …
27 results