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Page 1
The fibroblast growth factor receptor inhibitor, derazantinib, has strong efficacy in human gastric tumor models and synergizes with paclitaxel in vivo.
McSheehy PMJ, Forster-Gross N, El Shemerly M, Bachmann F, Roceri M, Hermann N, Spickermann J, Kellenberger L, Lane HA. McSheehy PMJ, et al. Among authors: spickermann j. Anticancer Drugs. 2023 Apr 1;34(4):532-543. doi: 10.1097/CAD.0000000000001469. Epub 2022 Dec 2. Anticancer Drugs. 2023. PMID: 36729959
Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072.
Paech F, Messner S, Spickermann J, Wind M, Schmitt-Hoffmann AH, Witschi AT, Howell BA, Church RJ, Woodhead J, Engelhardt M, Krähenbühl S, Maurer M. Paech F, et al. Among authors: spickermann j. Arch Toxicol. 2017 Nov;91(11):3647-3662. doi: 10.1007/s00204-017-1994-x. Epub 2017 May 23. Arch Toxicol. 2017. PMID: 28536862 Clinical Trial.
Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling.
Woodhead JL, Paech F, Maurer M, Engelhardt M, Schmitt-Hoffmann AH, Spickermann J, Messner S, Wind M, Witschi AT, Krähenbühl S, Siler SQ, Watkins PB, Howell BA. Woodhead JL, et al. Among authors: spickermann j. Clin Transl Sci. 2018 Sep;11(5):498-505. doi: 10.1111/cts.12560. Epub 2018 Jun 7. Clin Transl Sci. 2018. PMID: 29877622 Free PMC article.
Tissue Distribution and Elimination of Isavuconazole following Single and Repeat Oral-Dose Administration of Isavuconazonium Sulfate to Rats.
Schmitt-Hoffmann AH, Kato K, Townsend R, Potchoiba MJ, Hope WW, Andes D, Spickermann J, Schneidkraut MJ. Schmitt-Hoffmann AH, et al. Among authors: spickermann j. Antimicrob Agents Chemother. 2017 Nov 22;61(12):e01292-17. doi: 10.1128/AAC.01292-17. Print 2017 Dec. Antimicrob Agents Chemother. 2017. PMID: 28971866 Free PMC article.
Investigation of the species-dependent in vitro metabolism of BAL30630 by stable isotope labeling and isotope exchange experiments analyzed by capillary liquid chromatography coupled to mass spectrometry.
Wind M, Grunwald H, Gebhardt K, Illig K, Spickermann J, Nuoffer C, Roussel P, Klauer D, Fullhardt P, Schmitt-Hoffmann A, Schleimer M. Wind M, et al. Among authors: spickermann j. J Chromatogr A. 2009 May 1;1216(18):3946-53. doi: 10.1016/j.chroma.2009.03.022. Epub 2009 Mar 13. J Chromatogr A. 2009. PMID: 19327777
Elucidation of the in vitro metabolic profile of stable isotope labeled BAL19403 by accurate mass capillary liquid chromatography/quadrupole time-of-flight mass spectrometry and isotope exchange.
Wind M, Gebhardt K, Grunwald H, Spickermann J, Donzelli M, Kellenberger L, Muller M, Fullhardt P, Schmitt-Hoffmann A, Schleimer M. Wind M, et al. Among authors: spickermann j. Rapid Commun Mass Spectrom. 2007;21(7):1093-9. doi: 10.1002/rcm.2926. Rapid Commun Mass Spectrom. 2007. PMID: 17318924