Abstract
A series of N-(substituted pyridinyl)-1-methyl(phenyl)-3-trifluoromethyl-1H-pyrazole-4-carboxamide derivatives were synthesized. All target compounds were characterized by spectral data (¹H-NMR, ¹³C-NMR, IR, MS) and elemental analysis and were bioassayed in vitro against three kinds of phytopathogenic fungi (Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica). The results showed that some of the synthesized N-(substituted pyridinyl)-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamides exhibited moderate antifungal activities, among which compounds 6a, 6b and 6c displayed more than 50% inhibition activities against G. zeae at 100 µg/mL, which was better than that of the commercial fungicides carboxin and boscalid.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aminoimidazole Carboxamide* / analogs & derivatives
-
Aminoimidazole Carboxamide* / chemical synthesis
-
Aminoimidazole Carboxamide* / chemistry
-
Aminoimidazole Carboxamide* / pharmacology
-
Antifungal Agents / chemical synthesis
-
Antifungal Agents / chemistry
-
Antifungal Agents / pharmacology
-
Fungi / drug effects*
-
Fungi / pathogenicity
-
Fungicides, Industrial* / chemical synthesis
-
Fungicides, Industrial* / pharmacology
-
Magnetic Resonance Spectroscopy
-
Molecular Structure
-
Pyrazoles* / chemical synthesis
-
Pyrazoles* / chemistry
-
Pyrazoles* / pharmacology
-
Structure-Activity Relationship
Substances
-
Antifungal Agents
-
Fungicides, Industrial
-
Pyrazoles
-
Aminoimidazole Carboxamide