LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration.
Wu Y, Zhou L, Liu H, Duan R, Zhou H, Zhang F, He X, Lu D, Xiong K, Xiong M, Zhuang J, Liu Y, Li L, Liang D, Chen YH.
Wu Y, et al.
Cell Res. 2021 Apr;31(4):450-462. doi: 10.1038/s41422-020-00411-7. Epub 2020 Sep 24.
Cell Res. 2021.
PMID: 32973339
Free PMC article.
Cardiomyocyte-specific deletion of Lrp6 in the mouse heart induced a robust regenerative response after myocardial infarction (MI), led to reduced MI area and improvement in left ventricular systolic function. In vivo genetic lineage tracing revealed that the newly …
Cardiomyocyte-specific deletion of Lrp6 in the mouse heart induced a robust regenerative response after myocardial infarction (MI), l …