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A bioisosteric approach to the discovery of novel N-aryl-N'-[4-(aryloxy)cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation.
Kwak J, Kim MJ, Kim S, Park GB, Jo J, Jeong M, Kang S, Moon S, Bang S, An H, Hwang S, Kim MS, Yoo JW, Moon HR, Chang W, Chung KW, Jeong JY, Yun H. Kwak J, et al. Eur J Med Chem. 2022 Sep 5;239:114501. doi: 10.1016/j.ejmech.2022.114501. Epub 2022 May 29. Eur J Med Chem. 2022. PMID: 35716517
Physicochemical characterization and phase II metabolic profiling of echinochrome A, a bioactive constituent from sea urchin, and its physiologically based pharmacokinetic modeling in rats and humans.
Han DG, Kwak J, Choi E, Seo SW, Vasileva EA, Mishchenko NP, Fedoreyev SA, Stonik VA, Kim HK, Han J, Byun JH, Jung IH, Yun H, Yoon IS. Han DG, et al. Among authors: kwak j. Biomed Pharmacother. 2023 Jun;162:114589. doi: 10.1016/j.biopha.2023.114589. Epub 2023 Mar 31. Biomed Pharmacother. 2023. PMID: 37004327 Free article. Clinical Trial.