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Did you mean jirada tu (3 results)?
Nuclear transport proteins: structure, function, and disease relevance.
Yang Y, Guo L, Chen L, Gong B, Jia D, Sun Q. Yang Y, et al. Signal Transduct Target Ther. 2023 Nov 10;8(1):425. doi: 10.1038/s41392-023-01649-4. Signal Transduct Target Ther. 2023. PMID: 37945593 Free PMC article. Review.
In-depth knowledge of this rapidly evolving field has the potential to bring new insights into fundamental biology, pathogenic mechanisms, and therapeutic approaches....
In-depth knowledge of this rapidly evolving field has the potential to bring new insights into fundamental biology, pathogenic mechanisms, a …
SCGN deficiency is a risk factor for autism spectrum disorder.
Liu Z, Tan S, Zhou L, Chen L, Liu M, Wang W, Tang Y, Yang Q, Chi S, Jiang P, Zhang Y, Cui Y, Qin J, Hu X, Li S, Liu Q, Chen L, Li S, Burstein E, Li W, Zhang X, Mo X, Jia D. Liu Z, et al. Signal Transduct Target Ther. 2023 Jan 2;8(1):3. doi: 10.1038/s41392-022-01225-2. Signal Transduct Target Ther. 2023. PMID: 36588101 Free PMC article.
Our study also indicates that it is critical to identify and stratify ASD patient populations based on their disease mechanisms, which could greatly enhance therapeutic success....
Our study also indicates that it is critical to identify and stratify ASD patient populations based on their disease mechanisms, which could …
TBC1D23 mediates Golgi-specific LKB1 signaling.
Tu Y, Yang Q, Tang M, Gao L, Wang Y, Wang J, Liu Z, Li X, Mao L, Jia RZ, Wang Y, Tang TS, Xu P, Liu Y, Dai L, Jia D. Tu Y, et al. Nat Commun. 2024 Feb 27;15(1):1785. doi: 10.1038/s41467-024-46166-2. Nat Commun. 2024. PMID: 38413626 Free PMC article.
Allosteric inhibitors of the STAT3 signaling pathway.
Qin J, Shen X, Zhang J, Jia D. Qin J, et al. Eur J Med Chem. 2020 Mar 15;190:112122. doi: 10.1016/j.ejmech.2020.112122. Epub 2020 Feb 7. Eur J Med Chem. 2020. PMID: 32066011 Review.
Over-expression and/or hyperactivation of signal transducer and activator of transcription 3 (STAT3) signaling are found in various human diseases, including cancer, autoimmune disorders, and inflammatory diseases. Therefore, STAT3 represents a highly promising therapeutic …
Over-expression and/or hyperactivation of signal transducer and activator of transcription 3 (STAT3) signaling are found in various human di …
Structural and mechanistic insights into secretagogin-mediated exocytosis.
Qin J, Liu Q, Liu Z, Pan YZ, Sifuentes-Dominguez L, Stepien KP, Wang Y, Tu Y, Tan S, Wang Y, Sun Q, Mo X, Rizo J, Burstein E, Jia D. Qin J, et al. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6559-6570. doi: 10.1073/pnas.1919698117. Epub 2020 Mar 10. Proc Natl Acad Sci U S A. 2020. PMID: 32156735 Free PMC article.
GMPPB-congenital disorders of glycosylation associate with decreased enzymatic activity of GMPPB.
Liu Z, Wang Y, Yang F, Yang Q, Mo X, Burstein E, Jia D, Cai XT, Tu Y. Liu Z, et al. Mol Biomed. 2021 May 10;2(1):13. doi: 10.1186/s43556-021-00027-2. Mol Biomed. 2021. PMID: 35006422 Free PMC article.
However, the genotype-phenotype correlation remains elusive, limiting our understanding of the underlying mechanism and development of therapeutic strategy. Here, we report a case of an individual presenting congenital muscular dystrophy with cerebellar involvement, who pr …
However, the genotype-phenotype correlation remains elusive, limiting our understanding of the underlying mechanism and development of th …
Reduced thiamine binding is a novel mechanism for TPK deficiency disorder.
Huang W, Qin J, Liu D, Wang Y, Shen X, Yang N, Zhou H, Cai XT, Wang ZL, Yu D, Luo R, Sun Q, Xie YM, Jia D. Huang W, et al. Mol Genet Genomics. 2019 Apr;294(2):409-416. doi: 10.1007/s00438-018-1517-3. Epub 2018 Nov 27. Mol Genet Genomics. 2019. PMID: 30483896
Thus, our study provided a novel rationale for thiamine supplementation, so far the major therapeutic intervention in TPK deficiency....
Thus, our study provided a novel rationale for thiamine supplementation, so far the major therapeutic intervention in TPK deficiency. …
A thiazole-derived oridonin analogue exhibits antitumor activity by directly and allosterically inhibiting STAT3.
Shen X, Zhao L, Chen P, Gong Y, Liu D, Zhang X, Dai L, Sun Q, Lou J, Jin Z, Zhang B, Niu D, Chen C, Qi X, Jia D. Shen X, et al. J Biol Chem. 2019 Nov 15;294(46):17471-17486. doi: 10.1074/jbc.RA119.009801. Epub 2019 Oct 8. J Biol Chem. 2019. PMID: 31594861 Free PMC article.
Taken together, our findings suggest Cys-542 as a druggable site for selectively inhibiting STAT3 and indicate that CYD0618 represents a promising lead compound for developing therapeutic agents against STAT3-driven diseases....
Taken together, our findings suggest Cys-542 as a druggable site for selectively inhibiting STAT3 and indicate that CYD0618 represents a pro …