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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1941 1
1946 1
1947 1
1948 1
1950 1
1953 1
1954 2
1955 2
1956 2
1957 4
1958 2
1959 2
1960 5
1961 5
1962 6
1963 4
1964 25
1965 20
1966 13
1967 8
1968 16
1969 14
1970 20
1971 36
1972 33
1973 50
1974 22
1975 44
1976 56
1977 71
1978 61
1979 53
1980 45
1981 39
1982 44
1983 39
1984 41
1985 56
1986 50
1987 42
1988 53
1989 75
1990 63
1991 82
1992 144
1993 174
1994 235
1995 297
1996 345
1997 393
1998 417
1999 478
2000 514
2001 495
2002 481
2003 460
2004 466
2005 462
2006 498
2007 495
2008 530
2009 479
2010 573
2011 600
2012 635
2013 639
2014 683
2015 631
2016 781
2017 759
2018 768
2019 776
2020 945
2021 1075
2022 1083
2023 993
2024 345

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18,162 results

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The following term was not found in PubMed: Jia-Ch'ng
Page 1
Did you mean ji chang lok (4 results)?
Late-onset hypogonadism: a concept comes of age.
Nieschlag E. Nieschlag E. Andrology. 2020 Nov;8(6):1506-1511. doi: 10.1111/andr.12719. Epub 2019 Nov 15. Andrology. 2020. PMID: 31639279 Free article. Review.
LOH was classified as a combined primary and secondary hypogonadism since the endocrine capacity of the testes and the pituitary are impaired. ...Since these symptoms may also have origins other than LOH, exclusion of other disease entities and subnormal serum T lev …
LOH was classified as a combined primary and secondary hypogonadism since the endocrine capacity of the testes and the pituitary are …
A narrative review on inflammaging and late-onset hypogonadism.
Xing D, Jin Y, Jin B. Xing D, et al. Front Endocrinol (Lausanne). 2024 Jan 17;15:1291389. doi: 10.3389/fendo.2024.1291389. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38298378 Free PMC article. Review.
The increasing life expectancy observed in recent years has resulted in a higher prevalence of late-onset hypogonadism (LOH) in older men. LOH is characterized by the decline in testosterone levels and can have significant impacts on physical and mental health. ...A …
The increasing life expectancy observed in recent years has resulted in a higher prevalence of late-onset hypogonadism (LOH) in older …
Loss of heterozygosity in neuroblastomas--an overview.
Takita J, Hayashi Y, Yokota J. Takita J, et al. Eur J Cancer. 1997 Oct;33(12):1971-3. doi: 10.1016/s0959-8049(97)00292-x. Eur J Cancer. 1997. PMID: 9516835 Review.
Although previous studies have demonstrated a relatively high incidence of loss of heterozygosity (LOH) on chromosomes 1p, 11q and 14q in neuroblastoma, it is unclear whether LOH occurs specifically on these chromosomes or not. It might be due to the lack of allelot …
Although previous studies have demonstrated a relatively high incidence of loss of heterozygosity (LOH) on chromosomes 1p, 11q and 14 …
Microsatellite alteration in multiple primary lung cancer.
Shen C, Wang X, Tian L, Che G. Shen C, et al. J Thorac Dis. 2014 Oct;6(10):1499-505. doi: 10.3978/j.issn.2072-1439.2014.09.14. J Thorac Dis. 2014. PMID: 25364529 Free PMC article. Review.
It is important to determine if the second tumor represents an independent primary tumor or recurrence/metastasis, because it will significantly change the management and prognosis. Microsatellite instability (MSI) and loss of heterozygosity (LOH) represents molecular diso …
It is important to determine if the second tumor represents an independent primary tumor or recurrence/metastasis, because it will significa …
Testosterone therapy in older men with late-onset hypogonadism: a counter-rationale.
Basaria S. Basaria S. Endocr Pract. 2013 Sep-Oct;19(5):853-63. doi: 10.4158/EP13318.RA. Endocr Pract. 2013. PMID: 24014017 Review.
Prescription sales of testosterone have accordingly increased by 20-fold over the same period, due mainly to marketing campaign as well as to the failure of clinicians to distinguish organic hypogonadism from LOH. This review seeks to provide a counter-rationale for testos …
Prescription sales of testosterone have accordingly increased by 20-fold over the same period, due mainly to marketing campaign as well as t …
Ever since Knudson.
Devilee P, Cleton-Jansen AM, Cornelisse CJ. Devilee P, et al. Trends Genet. 2001 Oct;17(10):569-73. doi: 10.1016/s0168-9525(01)02416-7. Trends Genet. 2001. PMID: 11585662
However, to date the number of TSGs identified that are inactivated mainly at the somatic level in cancers and are not inherited has remained disappointingly small. Here we postulate that the accurate mapping of LOH events in a series of tumours to define a common LOH …
However, to date the number of TSGs identified that are inactivated mainly at the somatic level in cancers and are not inherited has remaine …
Loss of heterozygosity: what is it good for?
Ryland GL, Doyle MA, Goode D, Boyle SE, Choong DY, Rowley SM, Li J; Australian Ovarian Cancer Study Group; Bowtell DD, Tothill RW, Campbell IG, Gorringe KL. Ryland GL, et al. BMC Med Genomics. 2015 Aug 1;8:45. doi: 10.1186/s12920-015-0123-z. BMC Med Genomics. 2015. PMID: 26231170 Free PMC article.
METHODS: We analysed 86 ovarian carcinomas for mutations in 980 genes selected on the basis of their location in common regions of LOH. RESULTS: We identified 36 significantly mutated genes, but these could only partly account for the quanta of LOH in the samples. . …
METHODS: We analysed 86 ovarian carcinomas for mutations in 980 genes selected on the basis of their location in common regions of LOH …
[Role of androgen in the elderly. Clinical androgen replacement therapy for late-onset hypogonadism].
Amano T. Amano T. Clin Calcium. 2013 Aug;23(8):1179-84. Clin Calcium. 2013. PMID: 23892219 Review. Japanese.
Thus the principle of treatment for LOH is Androgen replacement therapy (ART) , and ART has been applied primarily in order to alleviate the various symptoms in LOH patients. The indication of ART for LOH is determined based on LOH symptoms assessed by …
Thus the principle of treatment for LOH is Androgen replacement therapy (ART) , and ART has been applied primarily in order to allevi …
Loss of heterozygosity in somatic cells of the mouse. An important step in cancer initiation?
Wijnhoven SW, Kool HJ, van Teijlingen CM, van Zeeland AA, Vrieling H. Wijnhoven SW, et al. Mutat Res. 2001 Jan 25;473(1):23-36. doi: 10.1016/s0027-5107(00)00163-9. Mutat Res. 2001. PMID: 11166024 Review.
In this paper, an overview is presented of recent studies in LOH-detecting mouse models. Molecular mechanisms that lead to LOH and the effects of genetic and environmental variables are discussed. ...LOH of tumour suppressor genes may thus be an initiating ev …
In this paper, an overview is presented of recent studies in LOH-detecting mouse models. Molecular mechanisms that lead to LOH …
Loss of Heterozygosity Spectrum Depends on Ploidy Level in Natural Yeast Populations.
Dutta A, Dutreux F, Schacherer J. Dutta A, et al. Mol Biol Evol. 2022 Nov 3;39(11):msac214. doi: 10.1093/molbev/msac214. Mol Biol Evol. 2022. PMID: 36205042 Free PMC article.
We found that the rate and spectrum of LOH are variable across ploidy levels. Of the total accumulated LOH events, 8.5%, 21%, and 70.5% of them were found in diploid, triploid, and tetraploid MA lines, respectively. Our results clearly show that the frequency of gen …
We found that the rate and spectrum of LOH are variable across ploidy levels. Of the total accumulated LOH events, 8.5%, 21%, …
18,162 results
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